Respiratory Syncytial Virus (RSV) Neutralizing Antibodies at Birth Predict Protection from RSV Illness in Infants in the First 3 Months of Life.
Respiratory Syncytial Virus (RSV) Neutralizing Antibodies at Birth Predict Protection from RSV Illness in Infants in the First 3 Months of Life.
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DOI：
10.1093/cid/ciaa648
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发表时间：
2021-12-06
期刊：
影响因子：
--
通讯作者：
Tapia MD
中科院分区：
文献类型：
--
作者：
Buchwald AG;Graham BS;Traore A;Haidara FC;Chen M;Morabito K;Lin BC;Sow SO;Levine MM;Pasetti MF;Tapia MD
呼吸道合胞病毒(RSV)是病毒性肺炎和毛细支气管炎的主要原因，在生命的前6个月。局部转移的抗体可以预防严重的RSV疾病，母体免疫可以减少幼儿的疾病。确定保护性抗体水平有助于提高候选疫苗和产妇免疫水平。我们对587对马里母婴进行了嵌套式病例对照研究，从出生到6个月。RSV病例是发生流感样疾病(ILI)或肺炎的婴儿，经聚合酶链式反应呈RSV阳性。这些病例与健康对照组和RSV阴性的ILI对照组相匹配。分别在3个月和6个月大时检测母血、脐带血和婴儿血清中的RSV-A和RSV-B中和抗体。母体抗体被有效地转移到婴儿身上。母亲和婴儿的RSV滴度有很强的相关性。婴儿抗RSV-A抗体效价是抗RSV-B抗体效价的3倍。在出生时，保持健康的婴儿的RSV-A和RSV-B滴度显著高于随后感染RSV的婴儿。与出生前3个月内的RSV病例相比，出生时RSV-A抑制浓度(IC)80滴度或RSV-B滴度60与健康对照显著相关。脐带血中的RSV-A IC80滴度与肺炎发作次数的减少有关。母体获得的RSV抗体与保护婴儿免受社区检测到的RSV-ILI和肺炎病例有关。脐带血中的RSV滴度可以预测婴儿是否会感染RSV或保持不受感染。母体获得的呼吸道合胞病毒(RSV)中和抗体与婴儿对RSV的保护作用相关，最长可达3个月。这些发现表明，出生时的RSV滴度可以预测婴儿是会感染RSV还是在早期生活中不会感染。
Respiratory syncytial virus (RSV) is a leading cause of viral pneumonia and bronchiolitis during the first 6 months of life. Placentally transferred antibodies can prevent severe RSV illness, and maternal immunization may reduce illness in young infants. Identification of protective antibody levels facilitates the advancement of vaccine candidates and maternal immunization. We conducted a nested case-control study with 587 Malian mother–infant pairs, followed from birth to age 6 months. RSV cases were infants who developed influenza-like illness (ILI) or pneumonia and were RSV-positive by polymerase chain reaction. Cases were matched to healthy controls and RSV-negative ILI controls. RSV-A and RSV-B neutralizing antibodies were measured in maternal, cord blood, and infant sera at age 3 and 6 months. Maternal antibodies were efficiently transferred to infants. Maternal and infant RSV titers were strongly correlated. Infant antibody titers against RSV-A were 3 times higher than those against RSV-B. At birth, infants who remained healthy had significantly higher RSV-A and RSV-B titers compared with infants who subsequently contracted RSV. RSV-A inhibitory concentration (IC)80 titer >239 or RSV-B titer >60 at birth was significantly associated with being a healthy control compared with an RSV case within the first 3 months of life. RSV-A IC80 titers in cord blood were associated with decreased episodes of pneumonia. Maternally acquired RSV antibodies were associated with protection of infants against community-detected cases of RSV-ILI and pneumonia. RSV titers in cord blood can predict whether an infant will be infected with RSV or remain uninfected. Maternally acquired respiratory syncytial virus (RSV) neutralizing antibodies were associated with infant protection against RSV up to 3 months. These findings indicate that RSV titers at birth can predict whether an infant will be infected with RSV or remain uninfected in early life.
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影响因子：
8
作者：
Bulkow, LR;Singleton, RJ;Harrison, LH
通讯作者：
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影响因子：
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作者：
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14.2
作者：
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