Transportation container for pre-processing cytogenetic assays in radiation accidents.
Transportation container for pre-processing cytogenetic assays in radiation accidents.
复制标题
运输容器,用于预处理辐射事故中的细胞遗传学测定。
DOI:
10.1038/s41598-021-89832-x
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发表时间:
2021-05-17
影响因子:
4.6
通讯作者:
Zenhausern F
中科院分区:
文献类型:
--
作者:
Gu J;Duane B;Repin M;Brenner DJ;Zenhausern F
We report a shipping container that enables a disruptive logistics for cytogenetic biodosimetry for radiation countermeasures through pre-processing cell culture during transportation. The container showed precise temperature control (< 0.01 °C) with uniform sample temperature (< 0.1 °C) to meet the biodosimetry assay requirements. Using an existing insulated shipping box and long shelf life alkaline batteries makes it ideal for national stockpile. Dose curve of cytogenetic biodosimetry assay using the shipping container showed clear dose response and high linear correlation with the control dose curve using a laboratory incubator (Pearson’s correlation coefficient: 0.992). The container’s ability of pre-processing biological samples during transportation could have a significant impact on radiation countermeasure, as well as potential impacts in other applications such as biobanking, novel molecular or cell-based assays or therapies.
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影响因子:
2.2
作者:
Sullivan JM;Prasanna PG;Grace MB;Wathen LK;Wallace RL;Koerner JF;Coleman CN
通讯作者:
Coleman CN
影响因子:
2.6
作者:
Garty, Guy;Karam, Andrew;Brenner, David J.
通讯作者:
Brenner, David J.
影响因子:
4
作者:
Nichols, Stephanie;Harvey, Alexandra;Bavister, Barry
通讯作者:
Bavister, Barry
影响因子:
3.3
作者:
Singh RK;Winkler P;Binette F;Glickman RD;Seiler M;Petersen-Jones SM;Nasonkin IO
通讯作者:
Nasonkin IO
影响因子:
3.4
作者:
Repin, Mikhail;Pampou, Sergey;Brenner, David J.
通讯作者:
Brenner, David J.