Cell Rover-a miniaturized magnetostrictive antenna for wireless operation inside living cells.
Cell Rover-a miniaturized magnetostrictive antenna for wireless operation inside living cells.
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DOI：
10.1038/s41467-022-32862-4
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发表时间：
2022-09-22
影响因子：
16.6
通讯作者：
Sarkar, Deblina
中科院分区：
文献类型：
--
作者：
Joy, Baju;Cai, Yubin;Bono, David C.;Sarkar, Deblina
细胞内天线可以为基础生物学和应用生物学开辟新的视野。在这里，我们介绍细胞漫游者，这是一种磁致伸缩天线，可以在活细胞内无线操作，并与3D生物系统兼容。它的尺寸小于毫米，由交流磁场声学驱动，并在低MHz频率下共振操作，这是活着的系统的理想选择。我们开发了一种使用非均匀磁场的细胞内注射方案，并在完全不透明的VI期非洲爪哇卵母细胞中演示了它们的操作，传统技术的实时成像对此具有挑战性。我们还表明，它们为多路复用应用提供了一条途径，以单独寻址多个小区或调谐到同一小区内的多个天线以实现多种功能。这项技术构成了基石，可以整合智能传感、调制以及能量采集等未来能力，为细胞内纳米电子计算提供动力，并有可能将信息技术的威力带入活细胞。这可能会带来前所未有的机会，让人们从根本上理解生物学以及诊断和治疗。能够真正实现对生物细胞的探测、调制或增强的细胞内天线仍然是一个尚未满足的挑战。在这里，作者介绍了Cell Rover，这是一种磁致伸缩天线，可以在活细胞内无线操作，并与3D生物系统兼容。
An intracellular antenna can open up new horizons for fundamental and applied biology. Here, we introduce the Cell Rover, a magnetostrictive antenna which can operate wirelessly inside a living cell and is compatible with 3D biological systems. It is sub-mm in size, acoustically actuated by an AC magnetic field and resonantly operated at low MHz frequencies, which is ideal for living systems. We developed an injection scheme involving non-uniform magnetic fields for intracellular injection of the Cell Rovers and demonstrated their operation in fully opaque, stage VI Xenopus oocytes, for which real-time imaging with conventional technologies is challenging. We also show that they provide a pathway for multiplexing applications to individually address multiple cells or to tune to more than one antenna within the same cell for versatile functionalities. This technology forms the foundation stone that can enable the integration of future capabilities such as smart sensing, modulation as well as energy harvesting to power in-cell nanoelectronic computing and can potentially bring the prowess of information technology inside a living cell. This could lead to unprecedented opportunities for fundamental understanding of biology as well as diagnostics and therapeutics. An intracellular antenna that can truly enable probing, modulation or augmentation of biological cells remains an unmet challenge. Here, the authors present the Cell Rover, a magnetostrictive antenna that operates wirelessly inside a living cell and is compatible with 3D biological systems.
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影响因子：
3.7
作者：
Du Pasquier D;Dupré A;Jessus C
通讯作者：
Jessus C
DOI：
10.1083/jcb.112.4.719
发表时间：
1991-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fushimi K;Verkman AS
通讯作者：
Verkman AS
影响因子：
38.3
作者：
Gomez-Martinez, Rodrigo;Hernandez-Pinto, Alberto M.;Plaza, Jose A.
通讯作者：
Plaza, Jose A.
影响因子：
3.2
作者：
Domann, John P.;Carman, Greg P.
通讯作者：
Carman, Greg P.
DOI：
10.3390/s110302809
发表时间：
2011
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Grimes CA;Roy SC;Rani S;Cai Q
通讯作者：
Cai Q