Theoretical models of the diffusion weighted MR signal.
Theoretical models of the diffusion weighted MR signal.
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DOI：
10.1002/nbm.1520
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发表时间：
2010-08
影响因子：
2.9
通讯作者：
Sukstanskii AL
中科院分区：
文献类型：
--
作者：
Yablonskiy DA;Sukstanskii AL
扩散 MRI 在研究健康和疾病的生物组织结构和功能方面发挥着非常重要的作用。对实验数据的正确解释需要开发理论模型，将扩散 MRI 信号与细胞水平上组织微观结构的显着特征联系起来。在这篇综述中，我们提出了一些模型（主要与大脑相关）来描述扩散衰减的 MR 信号。这些范围从最简单的方法（其中信号以表观扩散系数来描述）到相当复杂的模型（其中考虑源自细胞外和细胞内空间的信号，并考虑细胞的特定几何形状和方向分布）。为了更好地理解由整个组织的复杂结构产生的扩散衰减MR信号的特征，首先了解由简单的单细胞样结构产生的信号的特征是有启发性的。为此，我们还在此提出了模型的理论分析，允许对 MR 信号进行精确的分析计算，特别是具有不可渗透边界的单室模型和由可渗透膜分隔的相同细胞的周期性结构。这种纯理论模型为了解扩散存在下 MR 信号形成的机制提供了重要的见解。在这篇综述中，我们针对的是刚刚进入 MR 领域的科学家和对应用扩散方法研究生物组织感兴趣的经验丰富的 MR 研究人员。版权所有 © 2010 约翰威利父子有限公司
Diffusion MRI plays a very important role in studying biological tissue structure and functioning both in health and disease. Proper interpretation of experimental data requires development of theoretical models that connect the diffusion MRI signal to salient features of tissue microstructure at the cellular level. In this review, we present some models (mostly, relevant to the brain) for describing diffusion attenuated MR signals. These range from the simplest approach, where the signal is described in terms of an apparent diffusion coefficient, to rather complicated models, where consideration is given to signals originating from extra- and intracellular spaces and where account is taken of the specific geometry and orientation distribution of cells. To better understand the characteristics of the diffusion attenuated MR signal arising from the complex structure of whole tissue, it is instructive to appreciate first the characteristics of the signal arising from simple single-cell-like structures. For this purpose, we also present here a theoretical analysis of models allowing exact analytical calculation of the MR signal, specifically, a single-compartment model with impermeable boundaries and a periodic structure of identical cells separated by permeable membranes. Such pure theoretical models give important insights into mechanisms contributing to the MR signal formation in the presence of diffusion. In this review we targeted both scientists just entering the MR field and more experienced MR researchers interested in applying diffusion methods to study biological tissues. Copyright © 2010 John Wiley & Sons, Ltd.
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影响因子：
2.2
作者：
Callaghan, PT
通讯作者：
Callaghan, PT
影响因子：
2.2
作者：
Assaf, Y;Cohen, Y
通讯作者：
Cohen, Y
影响因子：
3.3
作者：
Anderson, AW
通讯作者：
Anderson, AW
影响因子：
4.4
作者：
BURRI, R;BIGLER, P;HERSCHKOWITZ, N
通讯作者：
HERSCHKOWITZ, N
影响因子：
--
作者：
DOUGLASS, DC;MCCALL, DW
通讯作者：
MCCALL, DW