Blood lead level and dental caries in school-age children.
Blood lead level and dental caries in school-age children.
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DOI：
10.1289/ehp.021100625
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发表时间：
2002-10
影响因子：
10.4
通讯作者：
Bellinger DC
中科院分区：
文献类型：
--
作者：
Gemmel A;Tavares M;Alperin S;Soncini J;Daniel D;Dunn J;Crawford S;Braveman N;Clarkson TW;McKinlay S;Bellinger DC
对参加儿童汞合金试验的543名6-10岁儿童的基线数据进行了横断面分析，评估了血铅水平与龋齿之间的关系。该试验旨在评估银质填充物中汞对健康的潜在影响。大约一半的儿童是从城市环境(波士顿/剑桥，美国马萨诸塞州)招募的，大约一半儿童来自农村环境(美国缅因州法明顿)。平均血铅水平在城市亚组中显著高于城市亚组，龋齿表面的平均数量也显著高于城市亚组。血铅水平与城市儿童的龋齿数量呈正相关，甚至与人口、母亲因素和儿童牙科实践的调整也呈正相关。这种联系在乳牙期比恒牙期强，在咬合、舌面和颊牙面比近中或远中牙面强。总体而言，在农村亚组中，血铅与龋齿无关。城市和农村环境中的联系强度之间的差异可能反映了前一种环境中存在剩余的混淆，后一种环境中在重要的龋齿风险因素(如氟化物暴露)方面存在更大的变异性，或者农村环境中存在更大的暴露错误分类。这些发现增加了支持儿童铅暴露与龋齿患病率之间微弱关联的证据。然而，铅致龋性的生物学机制尚未确定。我们的数据也与铅暴露升高和龋齿相关因素的残留混杂一致。
The association between blood lead level and dental caries was evaluated in cross-sectional analyses of baseline data for 543 children 6-10 years old screened for enrollment in the Children's Amalgam Trial, a study designed to assess potential health effects of mercury in silver fillings. Approximately half of the children were recruited from an urban setting (Boston/Cambridge, MA, USA) and approximately half from a rural setting (Farmington, ME, USA). Mean blood lead level was significantly greater among the urban subgroup, as was the mean number of carious tooth surfaces. Blood lead level was positively associated with number of caries among urban children, even with adjustment for demographic and maternal factors and child dental practices. This association was stronger in primary than in permanent dentition and stronger for occlusal, lingual, and buccal tooth surfaces than for mesial or distal surfaces. In general, blood lead was not associated with caries in the rural subgroup. The difference between the strength of the associations in the urban and rural settings might reflect the presence of residual confounding in the former setting, the presence of greater variability in the latter setting in terms of important caries risk factors (e.g., fluoride exposure), or greater exposure misclassification in the rural setting. These findings add to the evidence supporting a weak association between children's lead exposure and caries prevalence. A biologic mechanism for lead cariogenicity has not been identified, however. Our data are also consistent with residual confounding by factors associated with both elevated lead exposure and dental caries.
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影响因子：
158.5
作者：
NEEDLEMAN, HL;GUNNOE, C;BARRETT, P
通讯作者：
BARRETT, P
影响因子：
3.8
作者：
DIGREGORIO, GJ;FERKO, AP;CHERNICK, WS
通讯作者：
CHERNICK, WS
影响因子：
9.8
作者：
DRASCH, GA;BOHM, J;BAUR, C
通讯作者：
BAUR, C
影响因子：
3
作者：
Grobler, SR;Theunissen, FS;Kotze, TJV
通讯作者：
Kotze, TJV
影响因子：
3.5
作者：
BRODEUR, J;LACASSE, Y;TALBOT, D
通讯作者：
TALBOT, D