Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik.
Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik.
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产前暴露于PCB，汞和铅对婴儿认知的特异性影响：Nunavik的环境污染物和儿童发展研究的结果。
DOI：
10.1289/ehp.1206323
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发表时间：
2014-03
影响因子：
10.4
通讯作者：
Jacobson SW
中科院分区：
文献类型：
--
作者：
Boucher O;Muckle G;Jacobson JL;Carter RC;Kaplan-Estrin M;Ayotte P;Dewailly É;Jacobson SW
背景资料：多氯联苯（PCBs）、甲基汞（MeHg）和铅（Pb）是已知对认知发育有不利影响的环境污染物。目的：在这项研究中，我们研究了产前暴露于多氯联苯，甲基汞，铅对认知发育的因纽特人的婴儿从北极魁北克省的样本的影响。方法：在当地产前诊所招募母亲。多氯联苯，汞（Hg），铅，和两个海鲜营养素-二十二碳六烯酸（DHA）和硒（Se）-在脐带血中进行了测量。婴儿（n = 94）在6.5和11个月大时接受Fagan婴儿智力测试（FTII）、A-非B测试和贝利婴儿发育量表-第2版（BSID-II）评估。结果如下：多元回归分析显示，较高的产前PCB暴露与减少FTII新奇的偏好，表明受损的视觉识别记忆。产前汞与A-非B的表现较差有关，这取决于工作记忆，被认为是执行功能的前兆。出生前铅与较长的FTII固定时间有关，表明信息处理速度较慢。结论：多氯联苯，甲基汞，铅每一个都表现出特定的和不同的模式，在婴儿期测量的结果的不利影响。相比之下，这些暴露与BSID-II（一项全球发展指标）的表现无关。对这些暴露敏感的认知功能的更集中的窄带测量也提供了特定领域长期损害的早期迹象，否则这些损害在学龄前不太可能明显。引文：Boucher O，Muckle G，Jacobson JL，Carter RC，Kaplan-Estrin M，Ayotte P，Dewaily M，Jacobson SW. 2014.产前接触多氯联苯、汞和铅对婴儿认知的特定领域影响：努纳维克环境污染物和儿童发育研究结果环境健康展望122：310-316; http：dx.doi.org/10.1289/ehp.1206323
Background: Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development. Objectives: In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from Arctic Québec. Methods: Mothers were recruited at local prenatal clinics. PCBs, mercury (Hg), Pb, and two seafood nutrients—docosahexaenoic acid (DHA) and selenium (Se)—were measured in umbilical cord blood. Infants (n = 94) were assessed at 6.5 and 11 months of age on the Fagan Test of Infant Intelligence (FTII), A-not-B test, and Bayley Scales of Infant Development–2nd Edition (BSID-II). Results: Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing. Conclusions: PCBs, MeHg, and Pb each showed specific and distinct patterns of adverse associations with the outcomes measured during infancy. By contrast, none of these exposures was associated with performance on the BSID-II, a global developmental measure. The more focused, narrow band measures of cognitive function that appeared to be sensitive to these exposures also provide early indications of long-term impairment in specific domains that would otherwise not likely be evident until school age. Citation: Boucher O, Muckle G, Jacobson JL, Carter RC, Kaplan-Estrin M, Ayotte P, Dewailly É, Jacobson SW. 2014. Domain-specific effects of prenatal exposure to PCBs, mercury, and lead on infant cognition: results from the Environmental Contaminants and Child Development Study in Nunavik. Environ Health Perspect 122:310–316; http://dx.doi.org/10.1289/ehp.1206323
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