Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010.
Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010.
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口腔和口咽上皮发育不良中的人乳头瘤病毒 16 型和 18 型：荟萃分析，1985-2010 年。
DOI：
10.1016/j.oraloncology.2011.07.009
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发表时间：
2011
期刊：
影响因子：
4.8
通讯作者：
Sullivan,Maureen
中科院分区：
文献类型：
--
作者：
Jayaprakash,Vijayvel;Reid,Mary;Hatton,Elizabeth;Merzianu,Mihai;Rigual,Nestor;Marshall,James;Gill,Steve;Frustino,Jennifer;Wilding,Gregory;Loree,Thom;Popat,Saurin;Sullivan,Maureen
人乳头瘤病毒（HPV） 16型和18型与口腔和口咽鳞状细胞癌的亚群有因果关系。然而，对HPV-16/18在口腔和口咽发育不良（OOPD）中的患病率尚无明确的估计。本文献综述和荟萃分析旨在提供HPV-16/18在OOPD中的患病率估计。分析了22项报告458例卵巢外阴病变中HPV-16和/或18患病率的研究。采用荟萃分析评估HPV-16/18的患病率，并采用logistic回归对年龄、性别和组织学分级进行分层分析。HPV-16/18在OOPD病变中的总体患病率为24.5%[95%可信区间（CI）， 16.4-36.7%]。单独HPV-16的个体患病率为24.4%。HPV-16/18仅在口腔病变中的患病率为25.3% （95% CI, 14.2-45.2%）。男性在发育不良病变中检测HPV-16/18的几率是女性的2倍[比值比（OR）， 2.44]。与正常活检相比，HPV-16/18在发育不良病变（OR, 3.29; 95% CI, 1.95-5.53%）和浸润性癌症（OR, 3.43; 95% CI, 2.07-5.69%）中的发病率是正常活检的3倍。HPV-16/18在发育不良病变和癌症之间以及轻度、中度和重度发育不良病变之间的发生率无显著差异。本荟萃分析量化了16/18型HPV在卵巢外阴病变中的患病率。这些结果也支持HPV-16/18感染发生在口腔和口咽癌发生的早期阶段的假设。
Human papillomavirus (HPV) types 16 and 18 are causally related to a sub-set of oral cavity and oropharyngeal squamous cell cancers. However, a clear estimate of the prevalence of HPV-16/18 in oral cavity and oropharyngeal dysplasia (OOPD) is not available. This literature review and meta-analysis was conducted to provide a prevalence estimate for HPV-16/18 in OOPD. Twenty-two studies that reported prevalence of HPV-16 and/or 18 in 458 OOPD lesions were analyzed. Meta-analysis was used to evaluate the prevalence of HPV-16/18 and logistic regression was used for stratified analysis by age, gender, and histological grade. The overall prevalence of HPV-16/18 in OOPD lesions was 24.5% [95% confidence interval (CI), 16.4–36.7%)]. The individual prevalence for HPV-16 alone was 24.4%. The prevalence of HPV-16/18 in oral cavity lesions alone was 25.3% (95% CI, 14.2–45.2%). The odds of detection of HPV-16/18 in dysplastic lesions in males were twice that of females [odds ratio (OR), 2.44]. HPV-16/18 were 3 times more common in dysplastic lesions (OR, 3.29; 95% CI, 1.95–5.53%) and invasive cancers (OR, 3.43; 95% CI, 2.07–5.69%), when compared to normal biopsies. There was no significant difference in HPV-16/18 rates between dysplastic lesions and cancers or between mild, moderate or severe dysplastic lesions. This meta-analysis provides a quantification of the prevalence of HPV types 16/18 in OOPD lesions. These results also support the assumption that HPV-16/18 infection occurs during the early phase of the oral cavity and oropharyngeal carcinogenesis.
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影响因子：
6.4
作者：
Kreimer, AR;Alberg, AJ;Gillison, ML
通讯作者：
Gillison, ML
在不吸烟和饮酒的情况下，人乳头瘤病毒在口腔上皮发育不良和表皮样癌中的研究。
DOI：
--
发表时间：
1991
期刊：
Oral surgery, oral medicine, and oral pathology
影响因子：
--
作者：
R. Abdelsayed
通讯作者：
R. Abdelsayed
人乳头状瘤病毒（HPV）在癌前和恶性口腔粘膜病变中的出现频率高于正常粘膜。
影响因子：
3.6
作者：
T. Dodson
通讯作者：
T. Dodson
人乳头瘤病毒相关的口腔上皮发育不良（挖空细胞发育不良）：一种生物学潜力未知的实体。
DOI：
--
发表时间：
1996
期刊：
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
影响因子：
--
作者：
C. Allen;M. Fornatora;M. Fornatora;A. C. Jones;A. C. Jones;S. Kerpel;S. Kerpel;P. Freedman;P. Freedman
通讯作者：
P. Freedman
影响因子：
6.4
作者：
DEVILLIERS, EM;WEIDAUER, H;ZURHAUSEN, H
通讯作者：
ZURHAUSEN, H