Thymic Involvement in Immune Recovery During Antiretroviral Treatment of HIV Infection in Adults; comparison of CT and Sonographic Findings
Thymic Involvement in Immune Recovery During Antiretroviral Treatment of HIV Infection in Adults; comparison of CT and Sonographic Findings
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成人艾滋病毒感染的抗逆转录病毒治疗期间胸腺参与免疫恢复；
DOI：
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发表时间：
2002
影响因子：
--
通讯作者：
S. Nielsen
中科院分区：
文献类型：
--
作者：
L. Kolte;C. Strandberg;Anne;A. Ersbøll;D. Jeppesen;L. Ryder;S. Nielsen
在成人HIV感染患者中，CT扫描评估的胸腺大小似乎对高效抗逆转录病毒治疗（HAART）治疗期间获得的免疫重建程度很重要。为了检验超声是否与CT一样可靠，用于估计胸腺大小和预测免疫恢复，对25名成人HIV感染者和10名对照者进行了CT和超声扫描。测量CD 4计数和初始CD 4计数以确定免疫重建。此外，还测定了CD 4 + T细胞受体切除环（TREC）频率和T细胞受体（TCR）库。研究表明，2种扫描方法之间无相关性（患者中r = 0.201，p = 0.358，对照中r = 0.457，p = 0.184）。在这些患者中，超声估计的胸腺大小与免疫学参数（如CD 4计数）之间没有相关性（r = 0.083，p = 0.706），初始CD 4计数（r = 0.067，p = 0.762）、CD 4 + TREC频率（r = 0.028，p = 0.900）和CD 4 + TCR库（r =-0.057，p = 0.828）。这些发现表明，CT在评估成人胸腺大小方面仍具有上级优势，在评估HAART期间大胸腺对免疫恢复的重要性时，CT优于超声。
In adult HIV-infected patients, thymic size evaluated from CT scans seems to be important to the degree of immune reconstitution obtainable during treatment with highly active antiretroviral therapy (HAART). To examine whether ultrasound is as reliable as CT for estimating thymic size and predicting immune recovery, CT and ultrasound scans were performed in 25 adult HIV-infected patients and 10 controls. CD4 counts and naive CD4 counts were measured in order to determine immune reconstitution. Furthermore, the CD4+ T-cell receptor excision circle (TREC) frequency and T-cell receptor (TCR) repertoire were determined. The study demonstrated no correlation between the 2 scanning methods (r = 0.201, p = 0.358 in patients and r = 0.457, p = 0.184 in controls). Among the patients, no association was found between the sonographically estimated thymic size and immunological parameters such as CD4 count (r = 0.083, p = 0.706), naive CD4 count (r = 0.067, p = 0.762), CD4+ TREC frequency (r = 0.028, p = 0.900) and CD4+ TCR repertoire (r = -0.057, p = 0.828). These findings show that CT remains superior for assessing thymic size in adults and is preferable to ultrasound when evaluating the importance of a large thymus to immune recovery during HAART.
影响因子：
6.4
作者：
Smith, KY;Valdez, H;Lederman, MM
通讯作者：
Lederman, MM
影响因子：
15.9
作者：
McCune, JM;Loftus, R;Grant, RM
通讯作者：
Grant, RM