Breastfeeding and early white matter development: A cross-sectional study.
Breastfeeding and early white matter development: A cross-sectional study.
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DOI：
10.1016/j.neuroimage.2013.05.090
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发表时间：
2013-11-15
期刊：
影响因子：
5.7
通讯作者：
Dirks H
中科院分区：
文献类型：
--
作者：
Deoni SC;Dean DC 3rd;Piryatinsky I;O'Muircheartaigh J;Waskiewicz N;Lehman K;Han M;Dirks H
母乳喂养会改变大脑的早期发育吗？大型流行病学研究的普遍共识认为，早期纯母乳喂养与儿童后期和青春期智商和认知功能的改善有关。先前的脑形态学成像研究支持这些发现，揭示了与智商相关的白色物质和皮质下灰质体积增加，顶叶皮质厚度增加，与婴儿时期母乳喂养的青少年相比，那些完全配方奶粉喂养的青少年。然而，它仍然是未知的，当这些结构性差异首次表现出来，当发展的差异，预测以后的性能改善可以检测到。在这项研究中，我们使用安静的磁共振成像（MRI）扫描比较了133名10个月至4岁的健康儿童的白色微结构（髓鞘水分数的mcDESPOT测量），这些儿童要么纯母乳喂养至少3个月，要么纯配方奶粉喂养，要么接受母乳和配方奶粉的混合物。我们还研究了母乳喂养时间和白色物质显微结构之间的关系。母乳喂养的儿童表现出增加白色物质的发展，在成熟后的额叶和联合脑区。白色物质微观结构和母乳喂养持续时间之间的正相关关系也表现在几个大脑区域中，这与观察到的认知和行为表现指标的改善在解剖学上一致。虽然这些结构差异背后的机制尚不清楚，但我们的研究结果为与母乳喂养相关的早期发育优势提供了新的见解，并支持母乳成分促进健康神经生长和白色发育的假设。母乳喂养与婴儿早期脑髓鞘形成的初步研究。母乳喂养的婴儿在2岁时表现出大脑发育的改善。母乳喂养的持续时间与行为表现呈正相关。
Does breastfeeding alter early brain development? The prevailing consensus from large epidemiological studies posits that early exclusive breastfeeding is associated with improved measures of IQ and cognitive functioning in later childhood and adolescence. Prior morphometric brain imaging studies support these findings, revealing increased white matter and sub-cortical gray matter volume, and parietal lobe cortical thickness, associated with IQ, in adolescents who were breastfed as infants compared to those who were exclusively formula-fed. Yet it remains unknown when these structural differences first manifest and when developmental differences that predict later performance improvements can be detected. In this study, we used quiet magnetic resonance imaging (MRI) scans to compare measures of white matter microstructure (mcDESPOT measures of myelin water fraction) in 133 healthy children from 10 months through 4 years of age, who were either exclusively breastfed a minimum of 3 months; exclusively formula-fed; or received a mixture of breast milk and formula. We also examined the relationship between breastfeeding duration and white matter microstructure. Breastfed children exhibited increased white matter development in later maturing frontal and association brain regions. Positive relationships between white matter microstructure and breastfeeding duration are also exhibited in several brain regions, that are anatomically consistent with observed improvements in cognitive and behavioral performance measures. While the mechanisms underlying these structural differences remains unclear, our findings provide new insight into the earliest developmental advantages associated with breastfeeding, and support the hypothesis that breast milk constituents promote healthy neural growth and white matter development. First investigation of breast-feeding and early infant brain myelination. Breastfed infants shown improved brain development by 2 years of age. Duration of breastfeeding is positively associated with behavioral performance.
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DOI：
10.1186/1710-1492-9-15
发表时间：
2013
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Azad MB;Konya T;Maughan H;Guttman DS;Field CJ;Sears MR;Becker AB;Scott JA;Kozyrskyj AL
通讯作者：
Kozyrskyj AL
影响因子：
3.3
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
通讯作者：
Jones, Derek K.
影响因子：
4.8
作者：
Ahima, RS;Bjorbæk, C;Flier, JS
通讯作者：
Flier, JS
影响因子：
5.7
作者：
Kolind, Shannon;Matthews, Lucy;Johansen-Berg, Heidi;Leite, M. Isabel;Williams, Steven C. R.;Deoni, Sean;Palace, Jackie
通讯作者：
Palace, Jackie
影响因子：
3.8
作者：
Khedr, EHM;Farghaly, WMA;Osman, AAA
通讯作者：
Osman, AAA