Pyroptosis: A new insight of non-small-cell lung cancer treatment.
Pyroptosis: A new insight of non-small-cell lung cancer treatment.
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焦亡：非小细胞肺癌治疗的新见解
DOI：
10.3389/fonc.2022.1013544
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发表时间：
2022
影响因子：
4.7
通讯作者：
Wang, Jiabing
中科院分区：
文献类型：
--
作者：
Chen, Xi;Wu, Jianzhang;Wang, Jiabing
Non-small cell lung cancer (NSCLC) has become one of the most common malignant tumors. Emerging evidence has shown that tumor resistance to apoptosis by damaging or bypassing apoptotic cell death is a major contributor to poor responses to therapy in patients with NSCLC. Pyroptosis is a new type of cytolytic and inflammatory programmed death distinct from apoptosis. Currently, pyroptosis has been reported to cause a strong inflammatory response and significant tumor suppression. It is considered a promising therapeutic strategy and prognosis for NSCLC. In this review, we summarized the characteristics of pyroptosis from its underlying basis and role in NSCLC, thereby providing the potential of pyroptosis as a therapeutic strategy and highlighting the challenges of activating pyroptosis in NSCLC treatment.
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