Glucocorticoid receptor blockade inhibits brain cell addition and aggressive signaling in electric fish, Apteronotus leptorhynchus.
Glucocorticoid receptor blockade inhibits brain cell addition and aggressive signaling in electric fish, Apteronotus leptorhynchus.
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DOI：
10.1016/j.yhbeh.2011.06.001
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发表时间：
2011-08
影响因子：
3.5
通讯作者：
Pappas, Kristina M.
中科院分区：
文献类型：
--
作者：
Dunlap, Kent D.;Jashari, Denisa;Pappas, Kristina M.
关键词：
当动物处于压力之下时，糖皮质激素通常通过糖皮质激素受体（GR）发挥作用，抑制成体神经发生。然而，在某些情况下，糖皮质激素水平升高的情况会促进成人神经发生，而糖皮质激素受体在这些情况下的作用尚不清楚。我们研究了 GR 在电鱼 Apteronotus leptorhynchus 脑细胞添加和攻击性信号的社会性增强中的作用。在这个物种中，长期的社交互动同时会提高血浆皮质醇，增强脑细胞的添加并增加攻击性电通讯信号（“鸣叫声”）的产生。我们将分离并配对的鱼植入不含任何物质（对照）或 GR 拮抗剂 RU486 的胶囊，记录 7 天的鸣叫声产生和运动，并测量脑室周围区新生细胞的密度。与单独的对照组相比，配对对照组在两个阶段表现出较高的鸣叫声：前 5 小时的鸣叫率更高，此后的夜间鸣叫率稍高。用 RU486 处理成对鱼，两个阶段的鸣叫率均低于孤立鱼的鸣叫率，这表明 GR 激活对于社会诱导的鸣叫至关重要。 RU486 和社交互动都不影响运动。 RU486 处理配对鱼对细胞添加有部分影响：配对 RU486 鱼的细胞添加量少于配对对照鱼，但多于单独的鱼。这表明 GR 的皮质醇激活有助于细胞添加的社会性增强，但与另一种不依赖 GR 的机制并行作用。 RU486 还减少了离体鱼的细胞添加，表明即使皮质醇水平较低，GR 也参与细胞添加的调节。
When animals are under stress, glucocorticoids commonly inhibit adult neurogenesis by acting through glucocorticoid receptors (GRs). However, in some cases, conditions that elevate glucocorticoids promote adult neurogenesis, and the role of glucocorticoid receptors in these circumstances is not well understood. We examined the involvement of GRs in social enhancement of brain cell addition and aggressive signaling in electric fish, Apteronotus leptorhynchus. In this species, long-term social interaction simultaneously elevates plasma cortisol, enhances brain cell addition and increases production of aggressive electrocommunication signals (“chirps”). We implanted isolated and paired fish with capsules containing nothing (controls) or the GR antagonist, RU486, recorded chirp production and locomotion for 7d, and measured the density of newborn cells in the periventricular zone. Compared to isolated controls, paired controls showed elevated chirping in two phases: much higher chirp rates in the first 5 h and moderately higher nocturnal rates thereafter. Treating paired fish with RU486 reduced chirp rates in both phases to those of isolated fish, demonstrating that GR activation is crucial for socially induced chirping. Neither RU486 nor social interaction affected locomotion. RU486 treatment to paired fish had a partial effect on cell addition: paired RU486 fish had less cell addition than paired control fish but more than isolated fish. This suggests that cortisol activation of GRs contributes to social enhancement of cell addition but works in parallel with another GR-independent mechanism. RU486 also reduced cell addition in isolated fish, indicating that GRs participate in the regulation of cell addition even when cortisol levels are low.
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影响因子：
3.7
作者：
Chang, Ya-Ting;Chen, Yi-Chieh;Kuo, Yu-Min
通讯作者：
Kuo, Yu-Min
影响因子：
2.7
作者：
MALER, L;ELLIS, WG
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ELLIS, WG
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Gage, FH
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作者：
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通讯作者：
Prunet, P
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作者：
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通讯作者：
Benda, Jan