Prognostic value of Th17 cells in acute leukemia.
Prognostic value of Th17 cells in acute leukemia.
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DOI：
10.1007/s12032-013-0732-3
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Helal R
中科院分区：
文献类型：
--
作者：
Abousamra NK;Salah El-Din M;Helal R
Th 17细胞及其效应细胞因子已成为炎症和自身免疫性疾病的重要介质，并成为当前免疫学研究的一个雄心勃勃的领域。最近的研究表明Th 17细胞对实体瘤的潜在影响，但对其在血液恶性肿瘤中的作用知之甚少。本研究旨在探讨循环中Th 17细胞在急性白血病中的可能参与及其临床意义。采用流式细胞术检测93例急性白血病患者（ALL，n = 30; AML，n = 63）和40例健康志愿者外周血单个核细胞中Th 17细胞的百分比。采用酶联免疫吸附法测定血清IL-17和IL-21水平。急性白血病患者的循环Th 17细胞增加（ALL和AML患者分别为2.88 ± 0.65%和2.90 ± 0.57%），显著高于健康对照组（1.10 ± 0.28%; P = 0.001）。诱导治疗后达到完全缓解的患者治疗前Th 17细胞明显减少（ALL和AML患者分别为2.25 ± 0.44%和1.63 ± 0.27%，P < 0.0001）。急性白血病患者血清IL-17和IL-21水平显著升高。Kaplan-Meier曲线显示高Th 17水平患者的总生存期显著延长（ALL和AML分别为P = 0.029和P = 0.027）。在多变量分析中，ALL（OR 0.331; P = 0.043）和AML（OR 0.489; P = 0.032）患者中Th 17细胞对总生存率保持统计学显著性。这些结果强烈表明，Th 17细胞作为一个强大的新的预后决定因素，可以作为一个潜在的治疗靶点，以调节抗肿瘤反应的急性白血病患者。
Th17 cells and their effector cytokines have emerged as important mediators in inflammatory and autoimmune diseases and serve as an ambitious field in current immunology research. Recent studies suggest a potential impact of Th17 cells on solid tumors but relatively little is known about their contribution in hematological malignancies. The current study was designed to investigate the possible involvement and clinical significance of circulating Th17 cells in acute leukemia. Flow cytometry was used to analyze percentages of Th17 cells in peripheral blood mononuclear cells from 93 acute leukemia patients (ALL, n = 30; AML, n = 63) and 40 healthy volunteers. Serum levels of IL-17 and IL-21 were measured using enzyme-linked immunosorbent assay. Circulating Th17 cells were increased in patients with acute leukemia (2.88 ± 0.65 % and 2.90 ± 0.57 % in ALL and AML patients, respectively) and were significantly higher than in healthy controls (1.10 ± 0.28 %; P = 0.001). Furthermore, pretreatment Th17 cells were reduced significantly in patients who achieved complete remission after induction therapy (2.25 ± 0.44 % and 1.63 ± 0.27 % in ALL and AML patients, respectively, P < 0.0001). Serum levels of IL-17 and IL-21 were significantly elevated in acute leukemia patients. Kaplan–Meier curves revealed a significantly longer overall survival in patients with high Th17 levels (P = 0.029 and P = 0.027 for ALL and AML, respectively). In the multivariate analysis, Th17 cells retained statistical significance for overall survival in patients with ALL (OR 0.331; P = 0.043) and AML (OR 0.489; P = 0.032). These results strongly suggest Th17 cells as a powerful new prognostic determinant which could serve as a potential therapeutic target to modulate anti-tumor response in acute leukemia patients.
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影响因子：
20.3
作者：
Gowda, Aruna;Roda, Julie;Byrd, John C.
通讯作者：
Byrd, John C.
影响因子：
20.3
作者：
Kryczek, Ilona;Banerjee, Mousumi;Zou, Weiping
通讯作者：
Zou, Weiping
DOI：
10.1073/pnas.0509182102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Sato, E;Olson, SH;Odunsi, K
通讯作者：
Odunsi, K
急性髓性白血病患者外周血中 17 型辅助 T 细胞频率增加
影响因子：
4.6
作者：
Wu, C.;Wang, S.;Xu, H.
通讯作者：
Xu, H.
影响因子：
4.4
作者：
Kryczek, Ilona;Wei, Shuang;Zou, Weiping
通讯作者：
Zou, Weiping