Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child.
Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child.
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DOI：
10.1177/0883073809353449
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发表时间：
2010-07
影响因子：
1.9
通讯作者：
Donahue JE
中科院分区：
文献类型：
--
作者：
Brown WD;Bearer EL;Donahue JE
一名无症状、免疫功能正常的 8 岁女孩在新生儿时感染了该病毒，描述了一种独特形式的慢性、活动性、肉芽肿性单纯疱疹 2 型脑炎。偶然发现了广泛的双侧脑实质受累。通过一系列神经影像学、脑活检和针对糖蛋白 G 基因中 DNA 序列的定量聚合酶链反应的结合来确认诊断，从而区分 1 型和 2 型单纯疱疹病毒。详细回顾了 5 年期间的临床病程、间歇性静脉注射类固醇治疗和每日伐昔洛韦、诊断成像和实验室研究。这种形式的单纯疱疹病毒 2 型脑炎以前没有被描述过，但由于其长期惰性病程、缺乏神经系统发现或提示性病史以及这名现年 14 岁的孩子的良性行为，因此具有重要意义。作者认为，这种实体在一般儿科人群中可能未被怀疑和诊断不足，尤其是那些有 2 型单纯疱疹病毒感染史的母亲。
A unique form of chronic, active, granulomatous herpes simplex type 2 encephalitis is described in an asymptomatic, immunocompetent 8-year-old girl who acquired the virus as a neonate. The extensive, bilateral cerebral parenchymal involvement was discovered incidentally. Diagnosis was confirmed by a combination of serial neuroimaging, brain biopsy, and quantitative polymerase chain reaction targeted to DNA sequences in the glycoprotein G gene, allowing differentiation between herpes simplex virus types 1 and 2. The clinical course over a 5-year period, treatment with intermittent intravenous steroids, and daily valacyclovir, diagnostic imaging, and laboratory studies are reviewed in detail. This form of herpes simplex virus type 2 encephalitis hasn’t been described previously and is significant because of its prolonged indolent course, absence of neurological findings or suggestive history, and benign behavior in this child, who is now 14 years old. The authors believe this entity can be unsuspected and underdiagnosed in the general pediatric population, especially in those with a prior maternal history of herpes simplex virus type 2 infection.
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影响因子：
6
作者：
DUARTE, J;ARGENTE, J;CLAVERIA, LE
通讯作者：
CLAVERIA, LE
影响因子：
3.3
作者：
Gaviani, P;Leone, M;Monaco, F
通讯作者：
Monaco, F
影响因子：
9.9
作者：
JAY, V;BECKER, LE;ZIELENSKA, M
通讯作者：
ZIELENSKA, M
影响因子：
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作者：
GORDON, B;SELNES, OA;WHITLEY, RJ
通讯作者：
WHITLEY, RJ
影响因子：
1.4
作者：
BARTHEZ, MA;BILLARD, C;GRANGEPONTE, MC
通讯作者：
GRANGEPONTE, MC