The role of brain-derived neurotrophic factor in comorbid depression: possible linkage with steroid hormones, cytokines, and nutrition.
The role of brain-derived neurotrophic factor in comorbid depression: possible linkage with steroid hormones, cytokines, and nutrition.
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DOI：
10.3389/fpsyt.2014.00136
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发表时间：
2014
影响因子：
4.7
通讯作者：
Kunugi H
中科院分区：
文献类型：
--
作者：
Numakawa T;Richards M;Nakajima S;Adachi N;Furuta M;Odaka H;Kunugi H
越来越多的证据表明，生长因子功能(包括脑源性神经营养因子)、糖皮质激素水平(一种类固醇激素)与抑郁症的病理生理之间存在联系。由于脑源性神经营养因子和糖皮质激素都调节中枢神经系统中的突触功能，它们的功能相互作用是主要关注的问题。有趣的是，雌激素水平的变化，另一种类固醇激素，可能在产后女性的抑郁行为中发挥作用，大脑中BDNF相关分子的波动。BDNF和细胞因子是炎症的蛋白质调节因子，它们刺激与神经精神疾病有关的多种细胞内信号级联反应。促炎细胞因子可能会增加抑郁症状的易感性，例如癌症和/或自身免疫性疾病患者的风险增加。在这篇综述中，我们讨论了炎症和抑郁之间的可能关系，以及细胞因子、脑源性神经营养因子和类固醇之间的相互作用。此外，由于营养状况已被证明通过BDNF功能和单胺系统影响抑郁症的关键途径，我们还回顾了目前关于饮食和补充(例如，黄酮类)对BDNF介导的脑功能的影响的证据。
Increasing evidence demonstrates a connection between growth factor function (including brain-derived neurotrophic factor, BDNF), glucocorticoid levels (one of the steroid hormones), and the pathophysiology of depressive disorders. Because both BDNF and glucocorticoids regulate synaptic function in the central nervous system, their functional interaction is of major concern. Interestingly, alterations in levels of estrogen, another steroid hormone, may play a role in depressive-like behavior in postpartum females with fluctuations of BDNF-related molecules in the brain. BDNF and cytokines, which are protein regulators of inflammation, stimulate multiple intracellular signaling cascades involved in neuropsychiatric illness. Pro-inflammatory cytokines may increase vulnerability to depressive symptoms, such as the increased risk observed in patients with cancer and/or autoimmune diseases. In this review, we discuss the possible relationship between inflammation and depression, in addition to the cross-talk among cytokines, BDNF, and steroids. Further, since nutritional status has been shown to affect critical pathways involved in depression through both BDNF function and the monoamine system, we also review current evidence surrounding diet and supplementation (e.g., flavonoids) on BDNF-mediated brain functions.
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DOI：
10.1038/oby.2000.65
发表时间：
2000-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Chen, MD;Lin, PY
通讯作者：
Lin, PY
影响因子：
4.5
作者：
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通讯作者：
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DOI：
10.1073/pnas.1222142110
发表时间：
2013-06-11
影响因子：
11.1
作者：
Chowanadisai, Winyoo;Graham, David M.;Messerli, Mark A.
通讯作者：
Messerli, Mark A.
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
7.6
作者：
Barha, Cindy K.;Dalton, Gemma L.;Galea, Liisa A. M.
通讯作者：
Galea, Liisa A. M.