Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application.
Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application.
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DOI：
10.7150/ijbs.87492
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发表时间：
2023
影响因子：
9.2
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Deng B;Wang K;Zhang L;Qiu Z;Dong W;Wang W
光动力疗法（PDT）是一种有效针对癌症和炎症性疾病的微创治疗方法。它因其功效、低毒和重复使用的潜力而获得认可。结直肠癌 (CRC) 和炎症性肠病 (IBD)，包括克罗恩病 (CD) 和溃疡性结肠炎 (UC)，其发病率和患病率不断增加，给全球肠道健康带来了巨大负担。 PDT 作为一种新兴的胃肠道疾病治疗方法显示出前景，特别是 IBD 和 CRC。广泛的临床前研究已证明 PDT 对 IBD 和 CRC 的安全性和有效性，而临床研究目前正在进行中。本综述概述了 PDT 抗炎和抗肿瘤作用的潜在机制，为 PDT 在 IBD 和 CRC 治疗中的临床应用提供了见解。预计该综述将为未来CRC和IBD的PDT研究提供有价值的参考，为肠道炎症和癌症疾病的治疗进步做出贡献。
Photodynamic therapy (PDT) is a minimally invasive treatment that effectively targets cancer and inflammatory diseases. It has gained recognition for its efficacy, low toxicity, and potential for repeated use. Colorectal cancer (CRC) and inflammatory bowel diseases (IBD), including Crohn's disease (CD), and ulcerative colitis (UC), impose a significant burden on global intestinal health, with increasing incidence and prevalence rates. PDT shows promise as an emerging approach for gastrointestinal disease treatment, particularly IBD and CRC. Extensive preclinical research has demonstrated the safety and effectiveness of PDT for IBD and CRC, while clinical studies are currently underway. This review provides an overview of the underlying mechanisms responsible for the anti-inflammatory and anti-tumor effects of PDT, offering insights into the clinical application of PDT in IBD and CRC treatment. It is expected that this review will serve as a valuable reference for future research on PDT for CRC and IBD, contributing to advancements in the treatment of inflammatory and cancerous diseases of the intestines.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
3.7
作者：
Choi BH;Ryoo IG;Kang HC;Kwak MK
通讯作者：
Kwak MK
影响因子：
4.9
作者：
Emami, Fakhrossadat;Banstola, Asmita;Yook, Simmyung
通讯作者：
Yook, Simmyung
影响因子：
4.9
作者：
Bernstein, Charles N.;Fried, Michael;Watermeyer, Gillian
通讯作者：
Watermeyer, Gillian
低密度脂蛋白受体介导的苯二氧蛋白衍生物摄取的证据。
影响因子：
8.8
作者：
Allison, B A;Pritchard, P H;Levy, J G
通讯作者：
Levy, J G