Histological healing after nonsurgical periodontal treatment with enamel matrix derivatives in canine experimental periodontitis
Histological healing after nonsurgical periodontal treatment with enamel matrix derivatives in canine experimental periodontitis
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犬实验性牙周炎牙釉质基质衍生物非手术牙周治疗后的组织学愈合
DOI：
10.1007/s10266-018-0347-4
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发表时间：
2018
期刊：
影响因子：
2.5
通讯作者：
Izumi Yuichi
中科院分区：
文献类型：
--
作者：
Shujaa Addin Ammar;Akizuki Tatsuya;Matsuura Takanori;Hoshi Shu;Ikawa Takahiro;Maruyama Kiichi;Ono Wataru;Fukuba Shunsuke;Izumi Yuichi
釉基质衍生物（EMD）非手术牙周治疗后的组织学结果仍然存在争议。本研究评价了牙周洁治和根面平整术（SRP）联合应用EMD治疗实验性牙周炎后牙周创面的愈合情况。通过在6只比格犬的下颌第三和第四前磨牙周围应用丝线结扎诱导牙周膜破裂，直到放射学骨丢失进展到牙根长度的大约一半。结扎线移除后2周（基线），近端测量探测囊袋深度（PPD）和临床附着水平（CAL）。实验牙齿的近中面和远中面进行SRP，并使用裂口设计随机龈下应用EMD（测试）或生理盐水（对照）。PPD和CAL在11周时重新评估。在12周时处死动物进行组织学分析。在基线和第11周时，两组间PPD和CAL无显著差异。在组织学上，试验部位的新牙骨质数量明显多于对照部位（p< 0.01）。此外，与测试部位相比，对照部位显示上皮向下生长增加：（p< 0.05）。另一方面，在骨位置、结缔组织附着、牙龈退缩和牙根长度方面没有发现组间差异。这项研究表明，EMD有一个增加的潜力，以支持形成新的牙骨质减少上皮向下生长时，作为一种辅助非手术牙周治疗。
The histological outcomes after nonsurgical periodontal treatment with enamel matrix derivatives (EMD) remain controversial. The present study evaluated periodontal wound healing after scaling and root planing (SRP) with subgingival application of EMD for treatment of experimental periodontitis. Periodontal breakdown was induced by applying silk ligatures around mandibular third and fourth premolars of six beagle dogs until radiographic bone loss progressed to approximately half of the root length. Probing pocket depth (PPD) and clinical attachment level (CAL) were proximally measured 2 weeks after ligature removal (baseline). Mesial and distal surfaces of the experimental teeth were subjected to SRP and randomized using a split-mouth design to subgingival application of EMD (test) or normal saline (control). PPD and CAL were re-evaluated at 11 weeks. Animals were sacrificed at 12 weeks for histological analyses. No significant differences were observed in PPD and CAL between both groups at baseline and at 11 weeks. Histologically, test sites exhibited a greater amount of new cementum than that did the control sites (p< 0.01). Moreover, the control sites revealed increased epithelial downgrowth compared with the test sites: (p< 0.05). On the other hand, no intergroup differences were detected in terms of bone position, connective tissue attachment, gingival recession, and planed root length. This study suggested that EMD has an increased potential to support formation of new cementum with decreased epithelial downgrowth when used as an adjunct to nonsurgical periodontal treatment.
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影响因子：
6.7
作者：
Mombelli, A;Brochut, P;Giannopoulou, C
通讯作者：
Giannopoulou, C
牙釉质基质蛋白对牙牙龈区域伤口愈合的一些影响。
影响因子：
6.7
作者：
J. Wennström;J. Lindhe
通讯作者：
J. Lindhe
DOI：
--
发表时间：
1984
期刊：
The International journal of periodontics & restorative dentistry
影响因子：
--
作者：
M. R. Dragoo;D. Grant;D. Gutverg;R. Stambaugh
通讯作者：
R. Stambaugh
牙釉质基质衍生物与尼古丁存在下的引导组织再生：狗的组织形态学研究。
影响因子：
6.7
作者：
S. Pimentel;A. Sallum;J. B. Saldanha;M. Casati;F. Nociti;E. Sallum
通讯作者：
E. Sallum
影响因子：
6.7
作者：
Gestrelius, S;Andersson, C;Hammarstrom, L
通讯作者：
Hammarstrom, L