Why use a connectivity-based approach to study stroke and recovery of function?
Why use a connectivity-based approach to study stroke and recovery of function?
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DOI：
10.1016/j.neuroimage.2012.02.070
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发表时间：
2012-10-01
期刊：
影响因子：
5.7
通讯作者：
Corbetta, Maurizio
中科院分区：
文献类型：
--
作者：
Carter, Alex R.;Shulman, Gordon L.;Corbetta, Maurizio
大脑被组织成一组广泛分布的网络。因此，虽然中风造成的结构损伤是局灶性的，但与病变区域相连的区域可能会出现远程功能障碍。从历史上看，神经科学一直专注于本地处理，部分原因是缺乏研究分布式网络功能的工具。在本文中，我们讨论如何使用静息态功能连接 BOLD 磁共振成像（静息态 fcMRI）更全面地了解中风的影响。与任务诱发的 fMRI 相比，静息态 fcMRI 在研究中风后的大脑网络重组方面具有许多优势，包括对具有广泛损伤的受试者进行成像的能力以及同时研究多个网络的能力。我们描述了使用静息态连接作为研究异质中风患者群体中风恢复的神经基础的工具的基本原理，并讨论了我们希望回答的主要问题，特别是中风急性期的静息态 fcMRI 测量是否可以预测随后的恢复。早期结果表明，与受损或未受影响半球内的半球内连接相比，躯体运动网络和背侧注意力网络中半球间连接的破坏与这些区域的行为损伤更密切相关。我们还在躯体运动网络中观察到皮质脊髓束损伤和半球间连接减少之间有趣的相互作用，这表明这两个过程结合起来导致中风后的神经运动损伤。基于连接的方法将更深入地了解中风后急性和慢性阶段的网络重组，并将有助于提高预后能力和治疗干预措施的发展。
The brain is organized into a set of widely distributed networks. Therefore, although structural damage from stroke is focal, remote dysfunction can occur in regions connected to the area of lesion. Historically, neuroscience has focused on local processing due in part to the absence of tools to study the function of distributed networks. In this article we discuss how a more comprehensive understanding of the effects of stroke can be attained using resting state functional connectivity BOLD magnetic resonance imaging (resting state fcMRI). Resting state fcMRI has a number of advantages over task-evoked fMRI for studying brain network reorganization in response to stroke, including the ability to image subjects with a broad range of impairments and the ability to study multiple networks simultaneously. We describe our rationale for using resting state connectivity as a tool for investigating the neural substrates of stroke recovery in a heterogeneous population of stroke patients and discuss the main questions we hope to answer, in particular whether resting state fcMRI measures in the acute phase of stroke can predict subsequent recovery. Early results suggest that disruption of inter-hemispheric connectivity in the somatomotor network and the dorsal attention network is more strongly associated with behavioral impairment in those domains than is intra-hemispheric connectivity within either the lesioned or unaffected hemisphere. We also observe in the somatomotor network an interesting interaction between corticospinal tract damage and decreased inter-hemispheric connectivity that suggests that both processes combine to contribute to neuromotor impairment after stroke. A connectivity-based approach will provide greater insight into network reorganization in the acute and chronic phases after stroke and will contribute to improving prognostic ability and the development of therapeutic interventions.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
DOI：
10.1523/jneurosci.1776-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bressler SL;Tang W;Sylvester CM;Shulman GL;Corbetta M
通讯作者：
Corbetta M
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
11.2
作者：
CHOLLET, F;DIPIERO, V;FRACKOWIAK, RSJ
通讯作者：
FRACKOWIAK, RSJ
DOI：
10.1073/pnas.93.3.1249
发表时间：
1996-02-06
影响因子：
11.1
作者：
Buckner, RL;Corbetta, M;Petersen, SE
通讯作者：
Petersen, SE