The resting human brain and motor learning.
The resting human brain and motor learning.
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DOI：
10.1016/j.cub.2009.04.028
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发表时间：
2009-06-23
期刊：
影响因子：
--
通讯作者：
Miall RC
中科院分区：
文献类型：
--
作者：
Albert NB;Robertson EM;Miall RC
即使在没有明显行为的情况下，功能相关的大脑网络也会参与其中。这种静息状态活动（表现为血氧水平依赖（BOLD）的低频波动或电信号，相关综述见……）的作用尚不清楚。两种主要的观点是，静息状态活动支持内省性思维或支持对未来事件的反应。另一种观点是，静息的大脑积极且有选择性地处理过往的经历。在此我们表明，运动学习能够调节静息网络内随后的活动。在一次11分钟的视觉运动训练之前和之后的休息期间记录了血氧水平依赖信号。是运动学习而非运动表现调节了一个额顶叶静息状态网络（RSN）。除了额顶叶网络，一个先前未被报道为静息状态网络的小脑网络也因学习而发生了特异性改变。在学习类似的视觉运动任务期间，这两个网络都会参与。因此，我们首次描述了先前的学习（而非先前的表现）对特定静息状态网络的调节，揭示了学习的神经可塑性机制与静息状态活动之间的一种新联系。我们的方法可能为探索参与记忆巩固的系统提供一种有力的工具。
Functionally related brain networks are engaged even in the absence of an overt behavior. The role of this resting state activity, evident as low-frequency fluctuations of BOLD (see for review,) or electrical signals, is unclear. Two major proposals are that resting state activity supports introspective thought or supports responses to future events. An alternative perspective is that the resting brain actively and selectively processes previous experiences. Here we show that motor learning can modulate subsequent activity within resting networks. BOLD signal was recorded during rest periods before and after an 11 min visuomotor training session. Motor learning but not motor performance modulated a fronto-parietal resting state network (RSN). Along with the fronto-parietal network, a cerebellar network not previously reported as an RSN was also specifically altered by learning. Both of these networks are engaged during learning of similar visuomotor tasks. Thus, we provide the first description of the modulation of specific RSNs by prior learning—but not by prior performance—revealing a novel connection between the neuroplastic mechanisms of learning and resting state activity. Our approach may provide a powerful tool for exploration of the systems involved in memory consolidation.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.3
作者：
Lee, JH;van Donkelaar, P
通讯作者：
van Donkelaar, P
影响因子：
--
作者：
Halsband, Ulrike;Lange, Regine K.
通讯作者：
Lange, Regine K.
影响因子：
2.5
作者：
Baizer, JS;Kralj-Hans, I;Glickstein, M
通讯作者：
Glickstein, M
影响因子：
2.5
作者：
Obayashi, S;Suhara, T;Iriki, A
通讯作者：
Iriki, A