SARS-CoV-2 Causes a Different Cytokine Response Compared to Other Cytokine Storm-Causing Respiratory Viruses in Severely Ill Patients.
SARS-CoV-2 Causes a Different Cytokine Response Compared to Other Cytokine Storm-Causing Respiratory Viruses in Severely Ill Patients.
复制标题
SARS-CoV-2引起不同的细胞因子反应相比，其他细胞因子风暴引起的呼吸道病毒在重症患者。
DOI：
10.3389/fimmu.2021.629193
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发表时间：
2021
影响因子：
7.3
通讯作者：
Korcsmaros T
中科院分区：
文献类型：
--
作者：
Olbei M;Hautefort I;Modos D;Treveil A;Poletti M;Gul L;Shannon-Lowe CD;Korcsmaros T
促炎细胞因子的过度诱导，也称为细胞因子风暴或细胞因子释放综合征（CRS），是目前正在进行的SARS-CoV-2大流行的关键方面之一。当大量先天性和适应性免疫细胞激活并开始产生促炎细胞因子时，就会发生这个过程，从而建立一个加剧的炎症反馈回路。这是导致2019冠状病毒（COVID-19）患者亚组死亡的因素之一。CRS并不是SARS-CoV-2感染所独有的;它在过去二十年中大多数主要的人类冠状病毒和流感A亚型爆发中流行（H5 N1，SARS-CoV，MERS-CoV和H7N9）。通过全面的文献检索，我们收集了上述病毒病原体感染后患者细胞因子水平的变化。我们分析了已发表的患者数据，以突出这些病毒引起的保守和独特的细胞因子反应。我们的研究表明，SARS-CoV-2诱导的细胞因子反应与其他引起CRS的呼吸道病毒不同，因为SARS-CoV-2并不总是像其他冠状病毒或流感病毒那样诱导特异性细胞因子，如IL-2，IL-10，IL-4或IL-5。比较由分析的病毒引起的整理的细胞因子应答，突出了SARS-CoV-2特异性I型干扰素（IFN）应答及其下游细胞因子特征的失调。这项研究中收集的反应地图可以帮助专家确定缓解不同疾病中CRS的干预措施，并评估它们是否可以用于COVID-19病例。
Hyper-induction of pro-inflammatory cytokines, also known as a cytokine storm or cytokine release syndrome (CRS), is one of the key aspects of the currently ongoing SARS-CoV-2 pandemic. This process occurs when a large number of innate and adaptive immune cells activate and start producing pro-inflammatory cytokines, establishing an exacerbated feedback loop of inflammation. It is one of the factors contributing to the mortality observed with coronavirus 2019 (COVID-19) for a subgroup of patients. CRS is not unique to the SARS-CoV-2 infection; it was prevalent in most of the major human coronavirus and influenza A subtype outbreaks of the past two decades (H5N1, SARS-CoV, MERS-CoV, and H7N9). With a comprehensive literature search, we collected changing the cytokine levels from patients upon infection with the viral pathogens mentioned above. We analyzed published patient data to highlight the conserved and unique cytokine responses caused by these viruses. Our curation indicates that the cytokine response induced by SARS-CoV-2 is different compared to other CRS-causing respiratory viruses, as SARS-CoV-2 does not always induce specific cytokines like other coronaviruses or influenza do, such as IL-2, IL-10, IL-4, or IL-5. Comparing the collated cytokine responses caused by the analyzed viruses highlights a SARS-CoV-2-specific dysregulation of the type-I interferon (IFN) response and its downstream cytokine signatures. The map of responses gathered in this study could help specialists identify interventions that alleviate CRS in different diseases and evaluate whether they could be used in the COVID-19 cases.
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影响因子：
8
作者：
Califano D;Furuya Y;Roberts S;Avram D;McKenzie ANJ;Metzger DW
通讯作者：
Metzger DW
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