The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome.
The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome.
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J波综合征小电导钙激活钾电流的调节及性别二态性机制
DOI：
10.1007/s00424-020-02500-3
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Chen PS
中科院分区：
文献类型：
--
作者：
Chen M;Fei Y;Chen TZ;Li YG;Chen PS
Apamin-sensitive small-conductance calcium-activated potassium（SK）current（IKAS）在多种生理和病理条件下的心脏复极过程中起着重要作用。心脏IKAS的调节依赖于SK通道的表达、细胞内Ca ~（2+）以及SK通道与细胞内Ca ~（2+）的相互作用，IKAS的激活参与了多种类型的心律失常，包括心房颤动、室性快速心律失常、自律性和传导异常。近年来，在IKAS激活过程中发现了自主控制的性别二态性，导致了动作电位形态的性别分化和神经元的发生。本文就IKAS的钙依赖性调节及其在心律失常中的作用作一综述，并重点介绍IKAS激活的性别差异。我们认为IKAS自主控制的性别二态性可能在J波综合征中发挥作用。
Apamin-sensitive small-conductance calcium-activated potassium (SK) current (IKAS) plays an important role in cardiac repolarization under a variety of physiological and pathological conditions. The regulation of cardiacIKASrelies on SK channel expression, intracellular Ca2+, and interaction between SK channel and intracellular Ca2+.IKASactivation participates in multiple types of arrhythmias, including atrial fibrillation, ventricular tachyarrhythmias, and automaticity and conduction abnormality. Recently, sex dimorphisms in autonomic control have been noticed inIKASactivation, resulting in sex-differentiated action potential morphology and arrhythmogenesis. This review provides an update on the Ca2+-dependent regulation of cardiacIKASand the role ofIKASon arrhythmias, with a special focus on sex differences inIKASactivation. We propose that sex dimorphism in autonomic control ofIKASmay play a role in J wave syndrome.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
30.8
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通讯作者：
Kaeaeb, Stefan
心房颤动和心力衰竭病理生理学中的钙。
影响因子：
4
作者：
Denham NC;Pearman CM;Caldwell JL;Madders GWP;Eisner DA;Trafford AW;Dibb KM
通讯作者：
Dibb KM
影响因子：
5.5
作者：
Wu AZ;Chen M;Yin D;Everett TH 4th;Chen Z;Rubart M;Weiss JN;Qu Z;Chen PS
通讯作者：
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影响因子：
5.5
作者：
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通讯作者：
Chen PS