Mystery of rhythmic signal emergence within the suprachiasmatic nuclei
Mystery of rhythmic signal emergence within the suprachiasmatic nuclei
复制标题
视交叉上核内节律信号出现的奥秘
DOI：
10.1111/ejn.14141
复制
发表时间：
2018
影响因子：
3.4
通讯作者：
Vendula Čečmanová
中科院分区：
文献类型：
--
作者：
A. Sumová;Vendula Čečmanová
昼夜节律系统为生物体提供了一个时间组织，以24小时为基础优化其对环境波动的适应。在哺乳动物中，视交叉上核（SCN）的生物钟在围产期发育。节律性首先出现在胎儿阶段的单个SCN神经元水平，这一步骤经常被误解为SCN时钟发育完全的时间。然而，只有当SCN开始在体内发挥中央时钟的作用时，这一过程才最终完成，也就是说，当它们能够在细胞群水平上产生强大的节律性，通过外部光-暗周期将节律信号携带并传递给身体的其他部分时。这种发育是渐进的，与SCN的形态成熟有关，其结构复杂性基于细胞间网络的形成。这篇综述的目的是总结与胎儿SCN时钟首次出现昼夜节律振荡相关的事件。尽管已经积累了大量关于昼夜节律系统的个体发生的数据，但未成熟的SCN如何确切地转化为功能性的中央时钟仍然是相当难以捉摸的。在这篇综述中，关于SCN如何在组织水平上实现其节律性的假设是在该领域的最新进展的背景下讨论的。对于昼夜节律系统完整的个体发育的广泛总结，读者可参考其他先前发表的评论。
The circadian system provides organisms with a temporal organization that optimizes their adaptation to environmental fluctuations on a 24‐hr basis. In mammals, the circadian clock in the suprachiasmatic nuclei (SCN) develops during the perinatal period. The rhythmicity first appears at the level of individual SCN neurons during the fetal stage, and this step is often misinterpreted as the time of complete SCN clock development. However, the process is only finalized when the SCN begin to play a role of the central clock in the body, that is, when they are able to generate robust rhythmicity at the cell population level, entrain the rhythmic signal with external light‐dark cycles and convey this signal to the rest of the body. The development is gradual and correlates with morphological maturation of the SCN structural complexity, which is based on intercellular network formation. The aim of this review is to summarize events related to the first emergence of circadian oscillations in the fetal SCN clock. Although a large amount of data on ontogenesis of the circadian system have been accumulated, how exactly the immature SCN converts into a functional central clock has still remained rather elusive. In this review, the hypothesis of how the SCN attains its rhythmicity at the tissue level is discussed in context with the recent advances in the field. For an extensive summary of the complete ontogenetic development of the circadian system, the readers are referred to other previously published reviews.
登录
查看更多内容
10 日龄大鼠的松果体 N-乙酰转移酶活性：研究昼夜节律系统发育的范例。
影响因子：
4.8
作者：
Reppert,SM;Coleman,RJ;Heath,HW;Swedlow,JR
通讯作者：
Swedlow,JR
大鼠视交叉上核神经元活动的发育。
影响因子：
2.9
作者：
Shibata,S;Moore,RY
通讯作者：
Moore,RY
影响因子：
56.9
作者：
RALPH, MR;MENAKER, M
通讯作者：
MENAKER, M
影响因子：
56.9
作者：
RALPH, MR;FOSTER, RG;MENAKER, M
通讯作者：
MENAKER, M
定期喂养 SCN 受损的怀孕大鼠会影响胎儿的生物钟。
DOI：
10.1016/0165-3806(89)90292-7
发表时间：
1989
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Weaver,DR;Reppert,SM
通讯作者：
Reppert,SM