Building an open-source simulation platform of acoustic radiation force-based breast elastography.
Building an open-source simulation platform of acoustic radiation force-based breast elastography.
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DOI：
10.1088/1361-6560/aa58c9
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发表时间：
2017-03-07
影响因子：
3.5
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Wang Y;Peng B;Jiang J
基于超声的弹性成像，包括应变弹性成像（SE）、声辐射力脉冲（ARFI）成像、点剪切波弹性成像（pSWE）和超声剪切成像（SSI），已被用于在其他临床应用中区分乳腺肿瘤。本研究的目的是将先前发表的用于超声准静态乳腺弹性成像的虚拟仿真平台扩展到基于声辐射力的乳腺弹性成像。因此，扩展的虚拟乳房弹性成像模拟平台可用于验证复杂异质介质中具有已知潜在软组织特性（即“地面实况”）的图像像素，从而增强弹性成像图像解释的置信度。拟议的虚拟乳房弹性成像系统继承了四个关键组成部分，从以前发表的虚拟仿真平台：超声模拟器（场II），网格生成器（Tetgen），有限元求解器（FEBio）和可视化和数据处理包（VTK）。使用简单的消息传递机制，功能现已扩展到基于声辐射力的弹性成像模拟。涉及三个不同的数字乳房模型与日益增加的复杂性的例子-一个统一的模型，一个简单的包容模型和一个虚拟的复杂的乳房模型来自磁共振成像数据，被用来证明这个扩展的虚拟平台的能力。总体而言，模拟结果与公布的结果进行了比较。在均匀模型中，估计的剪切波速度（SWS）值与预定的SWS值相比在4%以内。在简单夹杂物和复杂乳房模型中，软背景中所有硬夹杂物的SWS值略有低估，与已报道的相似。弹性对比度值和目视观察表明，ARFI图像具有较高的空间分辨率，而SSI图像可以提供更高的包含体与背景的对比度。总之，我们的初步结果与我们的预期和文献报道一致。所提出的（开源）仿真平台可以作为一个单一的网关，以透明的方式执行许多弹性成像仿真，从而促进合作开发。
Ultrasound-based elastography including strain elastography (SE), acoustic radiation force Impulse (ARFI) imaging, point shear wave elastography (pSWE) and supersonic shear imaging (SSI) have been used to differentiate breast tumors among other clinical applications. The objective of this study is to extend a previously published virtual simulation platform built for ultrasound quasi-static breast elastography toward acoustic radiation force-based breast elastography. Consequently, the extended virtual breast elastography simulation platform can be used to validate image pixels with known underlying soft tissue properties (i.e. “ground truth”) in complex, heterogeneous media, enhancing confidence in elastographic image interpretations. The proposed virtual breast elastography system inherited four key components from the previously published virtual simulation platform: an ultrasound simulator (Field II), a mesh generator (Tetgen), a finite element solver (FEBio) and a visualization and data processing package (VTK). Using a simple message passing mechanism, functionalities have now been extended to acoustic radiation force-based elastography simulations. Examples involving three different numerical breast models with increasing complexity – one uniform model, one simple inclusion model and one virtual complex breast model derived from magnetic resonance imaging data, were used to demonstrate capabilities of this extended virtual platform. Overall, simulation results were compared with the published results. In the uniform model, the estimated shear wave speed (SWS) values were within 4% compared to the predetermined SWS values. In the simple inclusion and the complex breast models, SWS values of all hard inclusions in soft backgrounds were slightly underestimated, similar to what has been reported. The elastic contrast values and visual observation show that ARFI images have higher spatial resolution, while SSI images can provide higher inclusion-to-background contrast. In summary, our initial results were consistent with our expectations and what have been reported in the literature. The proposed (open-source) simulation platform can serve as a single gateway to perform many elastographic simulations in a transparent manner, thereby promoting collaborative developments.
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影响因子：
2.4
作者：
McGough, RJ
通讯作者：
McGough, RJ
影响因子：
2.9
作者：
Kallel, F;Prihoda, CD;Ophir, J
通讯作者：
Ophir, J
影响因子：
2.9
作者：
Madsen, EL;Hobson, MA;Frank, GR
通讯作者：
Frank, GR
DOI：
10.1001/jama.2015.12783
发表时间：
2015-10-20
期刊：
JAMA
影响因子：
--
作者：
Oeffinger KC;Fontham ET;Etzioni R;Herzig A;Michaelson JS;Shih YC;Walter LC;Church TR;Flowers CR;LaMonte SJ;Wolf AM;DeSantis C;Lortet-Tieulent J;Andrews K;Manassaram-Baptiste D;Saslow D;Smith RA;Brawley OW;Wender R;American Cancer Society
通讯作者：
American Cancer Society
影响因子：
10.6
作者：
Glatard, Tristan;Lartizien, Carole;Friboulet, Denis
通讯作者：
Friboulet, Denis