Reduction of fat accumulation and lipid disorders by individualized light aerobic training in human immunodeficiency virus infected patients with lipodystrophy and/or dyslipidemia.
Reduction of fat accumulation and lipid disorders by individualized light aerobic training in human immunodeficiency virus infected patients with lipodystrophy and/or dyslipidemia.
复制标题
通过对人类免疫缺陷病毒感染的脂肪营养不良和/或血脂异常患者进行个体化轻度有氧训练，减少脂肪积累和血脂紊乱。
作者：
G. Thöni;C. Fédou;J. Brun;J. Fabre;E. Renard;J. Reynes;A. Varray;J. Mercier
背景
管理腹部脂肪堆积和代谢紊乱的HIV 1感染患者，有氧训练计划，被认为是。
方法
17个脂肪营养不良和2血脂异常（无身体修改）的成年人进行了研究之前和4个月后的训练。训练负荷是个体化的基础上的解释性阈值，确定在最大运动测试的自行车功率计。通过CT扫描评估总（达特）、内脏（VAT）和皮下脂肪组织（SAT）。空腹过夜12小时后测定总胆固醇（TC）、高密度脂蛋白（HDL-C）、甘油三酯（TG）、乳酸（La）、胰岛素和葡萄糖。计算LDL、TC/HDL、TG/HDL、HOMA胰岛素抵抗指数及冠心病相对危险度（RR（CHD））。
结果
除了有氧适应性的显著改善外，训练的患者还表现出达特（-12.8%，p < 0.001）的降低，特别是在内脏水平（-12%，p < 0.01）以及TC、TG和La（分别为-23%，-43%和-19%，p < 0.01）。HDL-C升高（+6%，p < 0.01）。所有这些效应均高于通过可能回归到平均伪影而预期的变化。TC/HDL和TG/HDL均降低（p < 0.01），估计RR（CHD）降低约13%（p < 0.01）。在9个可用的HOMA上没有观察到显著的训练效果。血脂值的变化与基线测量值之间存在显著相关性（r范围为-0.55至-0.79，p < 0.05），表明基线血脂参数较高时改善幅度较大。
结论
有氧训练减少了HIV患者的内脏脂肪、血脂紊乱、基础血乳酸和CHD标志物。训练的效果对于明显血脂异常的患者尤为重要。
BACKGROUND
The management of abdominal fat accumulation and metabolic disorders in HIV1-infected patients, by an aerobic training program, is considered.
METHODS
Seventeen lipodystrophic and 2 dyslipidemic (without body modification) adults were studied before and after 4 months of training. The training load was individualized on a ventilatory threshold basis, determined during a maximal exercise test on cycle ergometer. Total (TAT), Visceral (VAT) and Subcutaneous Adipose Tissue (SAT) were assessed by CT-scan. Total (TC) and High Density Lipoprotein (HDL-C) Cholesterol, Triglycerides (TG), lactate (La), insulin and glucose were measured after a 12-hour-overnight fast. LDL, TC/HDL, TG/HDL, HOMA-insulin resistance index and coronary heart disease (CHD) relative risk (RR(CHD)) were calculated.
RESULTS
Besides a significant improvement of aerobic fitness, trained patients exhibited a reduction in TAT (-12.8%, p < 0.001), specially at the visceral level (- 12%, p < 0.01) and in TC, TG and La (- 23%, - 43% and - 19% respectively, p < 0.01). HDL-C was increased (+ 6%, p < 0.01). All these effects were above changes that could be expected by a possible regression to the mean artefact. Both TC/HDL and TG/HDL were reduced (p < 0.01) and the estimated RR(CHD) decreased by approximately 13% (p < 0.01). No significant training effect was observed on the 9 available HOMAs. Significant correlations were found between changes in blood lipid values and baseline measures (r range - 0.55 to - 0.79, p < 0.05), indicating a larger improvement when baseline lipid parameters were higher.
CONCLUSION
Aerobic training reduced visceral fat, lipid disorders, basal blood lactate and CHD markers in HIV patients. Training effects were particularly important for patients with marked dyslipidemia.
登录
查看更多内容
随着长时间的运动训练，高密度脂蛋白浓度和新陈代谢发生适度变化。
影响因子：
37.8
作者：
Thompson,PD;Cullinane,EM;Sady,SP;Flynn,MM;Bernier,DN;Kantor,MA;Saritelli,AL;Herbert,PN
通讯作者：
Herbert,PN
影响因子：
9.8
作者：
Leon, AS;Rice, T;Bouchard, C
通讯作者：
Bouchard, C
影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
一项运动训练试点研究，旨在减少患有艾滋病毒相关脂肪重新分布的成年人的躯干脂肪。
DOI：
10.1097/00002030-199907300-00015
发表时间：
1999
期刊：
AIDS (London, England)
影响因子：
--
作者：
Roubenoff,R;Weiss,L;McDermott,A;Heflin,T;Cloutier,GJ;Wood,M;Gorbach,S
通讯作者：
Gorbach,S
抗阻运动训练可降低接受抗病毒治疗的艾滋病毒感染男性的高甘油三酯血症。
DOI：
10.1152/jappl.2001.90.1.133
发表时间：
2001
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Yarasheski,KE;Tebas,P;Stanerson,B;Claxton,S;Marin,D;Bae,K;Kennedy,M;Tantisiriwat,W;Powderly,WG
通讯作者：
Powderly,WG