Task difficulty modulates the activity of specific neuronal populations in primary visual cortex.
Task difficulty modulates the activity of specific neuronal populations in primary visual cortex.
复制标题
任务难度调节初级视觉皮层中特定神经元群的活动。
DOI:
10.1038/nn.2147
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发表时间:
2008-08
影响因子:
25
通讯作者:
Alonso, Jose-Manuel
中科院分区:
文献类型:
--
作者:
Chen, Yao;Martinez-Conde, Susana;Macknik, Stephen L.;Bereshpolova, Yulia;Swadlow, Harvey A.;Alonso, Jose-Manuel
Spatial attention enhances our ability to detect stimuli at restricted regions of the visual field. This enhancement is thought to depend on the difficulty of the task being performed, but the underlying neuronal mechanisms for this dependency remain largely unknown. Here we demonstrate that task difficulty modulates neuronal firing rate at the earliest stages of cortical visual processing (area V1) in the macaque monkey. These modulations are spatially specific: increasing task difficulty enhances V1 neuronal firing rate at the focus of attention and suppresses it in regions surrounding the focus. Moreover, we show that response enhancement and suppression are mediated by distinct populations of neurons that differ in direction selectivity, spike width, interspike interval distribution and contrast sensitivity. Our results provide strong support for center-surround models of spatial attention and suggest that task difficulty modulates the activity of specific populations of neurons in the primary visual cortex.
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