Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers.
Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers.
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DOI：
10.1155/2020/8884450
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Wang D;Li M;Li J;Wan X;Huang Y;Wang C;Zhang P;Xu Y;Kong Z;Lu Y;Wang X;Liu C;Ji C;Li L
AR信号通路在前列腺癌、膀胱癌、肾癌、肺癌和乳腺癌等多种激素相关癌症的发生和发展中起着重要作用。然而，雄激素应答的长非编码RNA(LncRNAs)在激素相关癌症中的潜在作用尚不清楚。在目前的研究中，我们使用微阵列数据识别了469个新的雄激素反应LncRNA。在验证了阵列数据的准确性后，我们使用芯片序列数据构建了一个包含30多个转录因子的转录网络，以探索雄激素应答LncRNAs的上游调控因子。接下来，我们进行了生物信息学分析，以确定lncRNA-miRNA-mRNA调控网络。为了探索雄激素反应的lncRNAs在激素相关癌症中的潜在作用，我们使用TCGA数据进行了共表达网络和PPI网络分析。GO和KEGG分析表明，这些LncRNAs主要参与调控信号转导、转录、发育、细胞黏附、免疫反应、细胞分化和MAPK信号通路。我们还强调了HPN-AS1、TPTEP1和LINC00623在癌症预后中的预后价值。我们的结果表明，雄激素反应的lncRNAs在调节激素相关的癌症进展中起着重要作用，并可能成为新的分子生物标记物。
The AR signaling pathway plays an important role in initiation and progression of many hormone-related cancers including prostate, bladder, kidney, lung, and breast cancer. However, the potential roles of androgen-responsive long noncoding RNAs (lncRNAs) in hormone-related cancers remained unclear. In the present study, we identified 469 novel androgen-responsive lncRNAs using microarray data. After validating the accuracy of the array data, we constructed a transcriptional network which contained more than 30 transcriptional factors using ChIP-seq data to explore upstream regulators of androgen-responsive lncRNAs. Next, we conducted bioinformatics analysis to identify lncRNA-miRNA-mRNA regulatory network. To explore the potential roles of androgen-responsive lncRNAs in hormone-related cancers, we performed coexpression network and PPI network analyses using TCGA data. GO and KEGG analyses showed these lncRNAs were mainly involved in regulating signal transduction, transcription, development, cell adhesion, immune response, cell differentiation, and MAPK signaling pathway. We also highlight the prognostic value of HPN-AS1, TPTEP1, and LINC00623 in cancer outcomes. Our results suggest that androgen-responsive lncRNAs played important roles in regulating hormone-related cancer progression and could be novel molecular biomarkers.
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