Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster.
Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster.
复制标题
睡眠长度差异与果蝇果蝇的寿命改变有关。
DOI：
10.1242/bio.054361
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发表时间：
2020-09-16
期刊：
影响因子：
2.4
通讯作者：
Bauer JH
中科院分区：
文献类型：
--
作者：
Thompson JB;Su OO;Yang N;Bauer JH
睡眠不足已被证明会对健康结果产生负面影响，导致免疫反应降低、记忆力丧失、应激和炎症途径活动增加、体重增加，甚至行为改变。这些观察表明，睡眠剥夺实质上干扰了重要的生理功能，包括能量利用的代谢途径。这些表型中的许多与年龄相关，这表明睡眠中断可能会干扰衰老过程。然而，人们对睡眠中断如何影响衰老和长寿知之甚少。在这里，我们使用来自睡眠近交系(SIP)的八个有代表性的果蝇品系来研究这种关系。该系统由39个近交系组成，表现出极短和极长的睡眠模式，构成了研究睡眠调节机制的重要果蝇群落资源。我们的数据显示，与睡眠时间长的果蝇相比，睡眠时间短的果蝇寿命延长了16%，衰老速度也降低了。相比之下，打乱正常的昼夜节律会降低苍蝇的寿命。此外，与长睡眠线和昼夜节律紊乱的果蝇相比，短睡眠的果蝇表现出轻微的新陈代谢差异。这些数据表明，近亲交配的SIP线参与了与昼夜生物钟系统不同的睡眠机制。摘要：我们发现，睡眠模式缩短的果蝇可以降低衰老速度，延长寿命，而昼夜节律被打乱的果蝇则会降低寿命。我们的数据表明，昼夜节律和睡眠系统与衰老机制的相互作用是不同的。
Sleep deprivation has been shown to negatively impact health outcomes, leading to decreased immune responses, memory loss, increased activity of stress and inflammatory pathways, weight gain, and even behavioral changes. These observations suggest that sleep deprivation substantially interferes with important physiological functions, including metabolic pathways of energy utilization. Many of those phenotypes are correlated with age, suggesting that disrupted sleep may interfere with the aging process. However, little is known about how sleep disruption affects aging and longevity. Here, we investigate this relationship using eight representative fruit fly lines from the Sleep Inbred Panel (SIP). The SIP consists of 39 inbred lines that display extreme short- and long-sleep patterns, and constitutes a crucial Drosophila community resource for investigating the mechanisms of sleep regulation. Our data show that flies with short-sleep periods have ∼16% longer life span, as well as reduced aging rate, compared to flies with long-sleep. In contrast, disrupting normal circadian rhythm reduces fly longevity. Short-sleep SIP flies moreover show slight metabolic differences to long-sleep lines, and to flies with disrupted circadian rhythm. These data suggest that the inbred SIP lines engage sleep mechanisms that are distinct from the circadian clock system. Summary: We show that fruit flies with shortened sleep patterns have decreased aging rates and increased longevity, while flies with disrupted circadian rhythm have decreased longevity. Our data suggests that circadian and sleep systems interact differentially with mechanisms of aging.
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2.4
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