Towards a deeper understanding of the vaginal microbiota.
Towards a deeper understanding of the vaginal microbiota.
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DOI：
10.1038/s41564-022-01083-2
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发表时间：
2022-03
影响因子：
28.3
通讯作者：
Ravel J
中科院分区：
文献类型：
--
作者：
France M;Alizadeh M;Brown S;Ma B;Ravel J
人类阴道微生物群是阴道健康的关键决定因素。这些群落与阴道上皮密切相关，并依赖宿主组织作为资源。虽然通常由乳酸杆菌占主导地位，但阴道微生物群通常由兼性和专性厌氧菌的集合组成。这些缺乏乳酸菌的社区的患病率在妇女中各不相同，流行病学研究表明，这些社区与不良健康后果的风险增加有关。驱动这些关联的机制尚未详细描述，很少有研究建立因果关系。在这里，我们回顾了我们目前对阴道微生物群及其与宿主健康的关系的理解。我们的讨论围绕着乳酸菌属占主导地位时阴道微生物群的生物学，包括与塑造这些微生物群落有关的宿主因素以及由此产生的不良健康结果。我们讨论了目前调节阴道微生物群的方法，包括益生菌和阴道微生物群移植，并认为需要将阴道微生物群纳入宫颈阴道环境的新模型系统，以从关联进展到机制，这将证明对未来的研究是非常宝贵的。
The human vaginal microbiota is a critical determinant of vaginal health. These communities live in close association with the vaginal epithelium and rely on host tissues for resources. Although often dominated by lactobacilli, the vaginal microbiota is frequently comprised of a collection of facultative and obligate anaerobes. The prevalence of these communities with a paucity of Lactobacillus varies among women and epidemiological studies have associated them with an increased risk of adverse health outcomes. The mechanisms that drive these associations have yet to be described in detail with few studies establishing causative relationships. Here, we review our current understanding of the vaginal microbiota and its connection with host health. We center our discussion around the biology of the vaginal microbiota when Lactobacillus species are dominant versus when they are not, including host factors that are implicated in shaping these microbial communities and the resulting adverse health outcomes. We discuss current approaches to modulate the vaginal microbiota, including probiotics and vaginal microbiome transplants, and argue that novel model systems of the cervicovaginal environment that incorporate the vaginal microbiota are needed to progress from association to mechanism and this will prove invaluable for future research.
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影响因子：
3.1
作者：
Balkus JE;Richardson BA;Rabe LK;Taha TE;Mgodi N;Kasaro MP;Ramjee G;Hoffman IF;Abdool Karim SS
通讯作者：
Abdool Karim SS
影响因子：
16.6
作者：
Balle C;Konstantinus IN;Jaumdally SZ;Havyarimana E;Lennard K;Esra R;Barnabas SL;Happel AU;Moodie Z;Gill K;Pidwell T;Karaoz U;Brodie E;Maseko V;Gamieldien H;Bosinger SE;Myer L;Bekker LG;Passmore JS;Jaspan HB
通讯作者：
Jaspan HB
DOI：
10.1086/657320
发表时间：
2010-12-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brotman RM;Klebanoff MA;Nansel TR;Yu KF;Andrews WW;Zhang J;Schwebke JR
通讯作者：
Schwebke JR
DOI：
10.1016/j.ijbiomac.2020.02.065
发表时间：
2020-05-01
影响因子：
8.2
作者：
Abramov, Vyacheslav M.;Kosarev, Igor V.;Karlyshev, Andrey V.
通讯作者：
Karlyshev, Andrey V.
影响因子：
9.4
作者：
BRISELDEN, AM;MONCLA, BJ;HILLIER, SL
通讯作者：
HILLIER, SL