Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection.
Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection.
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DOI：
10.1086/657320
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发表时间：
2010-12-15
期刊：
影响因子：
--
通讯作者：
Schwebke JR
中科院分区：
文献类型：
--
作者：
Brotman RM;Klebanoff MA;Nansel TR;Yu KF;Andrews WW;Zhang J;Schwebke JR
我们试图评估细菌性阴道病（BV）的革兰氏染色和偶发性滴虫（TV），淋球菌（GC）和/或衣原体（CT）生殖器感染之间的关系。在亚拉巴马伯明翰的12家诊所接受常规护理的3，620名年龄在15-44岁的非妊娠女性参加了一项纵向研究。参与者每季度进行评估，为期一年。通过Nugent革兰氏染色评分对阴道涂片进行分类（0-3表示正常，4-6表示中间状态，7-10 BV）。使用合并logistic回归估计风险比（HR），以比较既往访视时按Nugent类别列出的受试者TV/GC/CT发生率。参与者在首次TV/GC/CT阳性访视时被删失。在10，606次就诊中，37.96%被归类为BV，13.3%被归类为TV/GC/CT阳性。既往访视时的中间状态或BV与TV/GC/CT感染事件风险增加1.5-2倍相关（校正HR（aHR）：1.41，95% CI：1.12-1.76; aHR：1.73，95% CI：1.42-2.11，趋势检验p= 0.058）。仅TV、仅GC和仅CT结局的估计值相似。通过革兰氏染色测量的BV微生物群与获得TV/GC/CT生殖器感染的风险显著升高相关。
We sought to assess the relationship between bacterial vaginosis (BV) assessed by Gram stain and incident trichomonal (TV), gonococcal (GC) and/or chlamydial (CT) genital infection. 3,620 non-pregnant women aged 15-44 presenting for routine care at 12 clinics in Birmingham, Alabama participated in a longitudinal study. Participants were assessed quarterly for one year. Vaginal smears were categorized by Nugent's Gram stain score (0-3 designated normal, 4-6 intermediate state, 7-10 BV). Pooled logistic regression was used to estimate the hazard ratios (HR) for the comparison of TV/GC/CT incidence in participants by Nugent category at the prior visit. Participants were censored at their first TV/GC/CT-positive visit. Of the 10,606 visits, 37.96% were classified as BV and 13.3% as TV/GC/CT-positive. Intermediate state or BV at the prior visit were associated with a 1.5-2-fold increased risk for incident TV/GC/CT infection (adjusted HR(aHR):1.41, 95% CI:1.12-1.76; aHR: 1.73, 95% CI: 1.42-2.11, respectively, test for trend p=.058). Estimates were similar for TV-only, GC-only and CT-only outcomes. BV microbiota gauged by Gram's stain is associated with a significantly elevated risk for acquisition of TV/GC/CT genital infection.
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影响因子：
9.8
作者：
Nansel, TR;Riggs, MA;Klebanoff, MA
通讯作者：
Klebanoff, MA
影响因子：
1.3
作者：
MCGRORY, T;MEYSICK, K;GARBER, GE
通讯作者：
GARBER, GE
影响因子：
6.4
作者：
Martin, HL;Richardson, BA;Kreiss, J
通讯作者：
Kreiss, J
影响因子：
11.8
作者：
Eschenbach, DA;Thwin, SS;Stamm, WE
通讯作者：
Stamm, WE
影响因子：
11.8
作者：
Cherpes, TL;Meyn, LA;Hillier, SL
通讯作者：
Hillier, SL