The fMRI success rate of children and adolescents: typical development, epilepsy, attention deficit/hyperactivity disorder, and autism spectrum disorders.
The fMRI success rate of children and adolescents: typical development, epilepsy, attention deficit/hyperactivity disorder, and autism spectrum disorders.
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DOI：
10.1002/hbm.20767
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发表时间：
2009-10
影响因子：
4.8
通讯作者：
Gaillard, William D.
中科院分区：
文献类型：
--
作者：
Yerys, Benjamin E.;Jankowski, Kathryn F.;Shook, Devon;Rosenberger, Lisa R.;Barnes, Kelly Anne;Berl, Madison M.;Ritzl, Eva K.;VanMeter, John;Vaidya, Chandan J.;Gaillard, William D.
儿童功能磁共振成像越来越多地用于临床应用和发育研究，然而，很少有人知道如何儿科患者和典型的发展中国家的人口成功地完成研究。我们检查了癫痫、注意力缺陷/多动障碍（ADHD）、自闭症谱系障碍（ASD）和典型发育儿童（TYP）的儿科成功率。我们还研究了年龄的影响，对于ADHD人群，药物治疗状况对成功率的影响。我们定义了一个成功的功能磁共振成像个人运行时，数据是可解释的，并包括在组统计。对于不成功的跑步，在可能的情况下对具有过度运动或地板任务性能的数据集进行分类。所有临床组的扫描成功率均低于对照组;药物状态不影响ADHD成功率（癫痫：80%; ADHD（停用哌甲酯）：77%; ADHD（使用哌甲酯）：81%; ASD：70%; TYP：87%）。10至18岁的儿童的扫描成功率明显高于4-6岁的儿童;青少年（13-18岁）的扫描成功率高于7-9岁的儿童。完成一整套实验运行（n=2-6）的成功率在患者人群的50-59%和TYP的69%之间变化（排除4-6岁儿童时为79%）。除ASD（81%）外，所有组完成一次电池运行的成功率均大于90%。这些数据表明，在这些患者组中应招募20-30%的儿童，但对于TYP研究，仅需招募10-20%的儿童。4-6岁儿童的研究可能需要20-40%的额外参与者; 10-18岁儿童的研究可能需要10-15%的额外参与者。
FMRI in children is increasingly used in clinical application and in developmental research; however, little is known how pediatric patient and typically developing populations successfully complete studies. We examined pediatric success rates with Epilepsy, Attention Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorders (ASD), and typically developing children (TYP). We also examined the affect of age, and, for ADHD populations, medication status on success rates. We defined a successful fMRI individual run when the data were interpretable and included in group statistics. For unsuccessful runs, datasets with excessive motion or floor task performance were categorized when possible. All clinical groups scanned less successfully than controls; medication status did not affect ADHD success (Epilepsy: 80%; ADHD (off methylphenidate): 77%; ADHD (on methylphenidate): 81%; ASD: 70%; TYP: 87%). Ten to 18-year-olds had a significantly greater scan success rate than 4–6-year-olds; adolescents (13–18-year-olds) demonstrated greater scan success rates than 7–9-year-olds. Success rate for completing an entire battery of experimental runs (n=2–6), varied between 50–59% for patient populations and 69% for TYP (79% when excluding 4–6-year-olds). Success rate for completing one run from a battery was greater than 90% for all groups, except for ASD (81%). These data suggest 20–30% more children should be recruited in these patient groups, but only 10–20% for TYP for research studies. Studies with 4–6-year-olds may require 20–40% additional participants; studies with 10–18-year-olds may require 10–15% additional participants.
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