Bioelectrical impedance analysis as a quantitative measure of sarcopenia in head and neck cancer patients treated with radiotherapy.
Bioelectrical impedance analysis as a quantitative measure of sarcopenia in head and neck cancer patients treated with radiotherapy.
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DOI：
10.1016/j.radonc.2021.03.005
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Rosenthal DI
中科院分区：
文献类型：
--
作者：
Grossberg AJ;Rock CD;Edwards J;Mohamed ASR;Ruzensky D;Currie A;Rosemond P;Phan J;Gunn GB;Frank SJ;Morrison WH;Garden AS;Fuller CD;Rosenthal DI
Sarcopenia is associated with decreased survival in head and neck cancer patients treated with radiotherapy. This study sought to determine whether in-clinic multifrequency bioelectrical impedance analysis (BIA) can identify survival-associated sarcopenia in patients with head and neck cancer. This prospective observational study enrolled 50 patients with head and neck cancer undergoing radiation therapy. Baseline BIA measures of skeletal muscle (SM) mass, fat-free mass (FFM), and fat mass (FM) were compared to CT-based estimates using linear regression. Sex-specific BIA-derived thresholds for sarcopenia were defined by the maximum Youden Index on receiver operator characteristic (ROC) curves. Patients were stratified by sarcopenia status and OS was compared using the Kaplan-Meier method and log-rank test. Among 48 evaluable patients, BIA measures of body composition were strongly correlated with CT measures: SM mass (r = 0.97; R2 = 0.94; p < 0.0001), FFM (r = 0.97; R2 = 0.94; p < 0.0001) and FM (r = 0.95; R2 = 0.90; p < 0.0001). SM mass index < 9.19 kg/m2 identified sarcopenia men with high sensitivity (91.7%) and specificity (92.9%), whereas in women SM mass index < 6.53 kg/m2 was sensitive for sarcopenia (100%), but not specific. Patients with sarcopenia, defined by either CT or BIA, exhibited decreased OS (HR=not estimable; CT p = 0.009; BIA p = 0.03). BIA provides accurate estimates of body composition in head and neck cancer patients. Implementation of BIA in clinical practice may identify patients with sarcopenia at risk for poor survival.
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影响因子：
3.7
作者：
Małecka-Massalska T;Mlak R;Smoleń A;Brzozowska A;Surtel W;Morshed K
通讯作者：
Morshed K
影响因子：
3.3
作者：
Shen, W;Punyanitya, M;Heshka, S
通讯作者：
Heshka, S
影响因子：
2.3
作者：
Buentzel, Judith;Micke, Oliver;Muecke, Ralph
通讯作者：
Muecke, Ralph
影响因子：
2.6
作者：
Chargi, N.;Bril, S., I;de Bree, R.
通讯作者：
de Bree, R.
影响因子：
2.6
作者：
Axelsson, Lars;Silander, Ewa;Hammerlid, Eva
通讯作者：
Hammerlid, Eva