Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke families.
Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke families.
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止血的遗传学：遗传力和家庭成分的差异影响影响282个小儿中风家族中脂质浓度和凝血因子水平的差异。
DOI：
10.1289/ehp.10754
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发表时间：
2008-06
影响因子：
10.4
通讯作者：
Stoll M
中科院分区：
文献类型：
--
作者：
Nowak-Göttl U;Langer C;Bergs S;Thedieck S;Sträter R;Stoll M
确定可能影响风险状况的遗传和环境因素应该是寻找共同环境影响(C2)调节疾病风险的变异比例的先决条件。在儿童早期首次发生急性缺血性中风的家庭中，缺乏这样的流行病学方法。我们的目标是估计血脂浓度和凝血因子水平内的表型变化，并估计可归因于遗传性(H2r)和c2的比例在儿童卒中家族中。采自282个白人中风家系的1002个个体的血液样本。我们用序贯寡核苷酸连锁分析中的方差分析方法估计了脂蛋白(A)[Lp(A)]、胆固醇、高密度脂蛋白、低密度脂蛋白、纤维蛋白原、凝血因子II、Fv、FVIIIC、von Willebrand因子、抗凝血酶、蛋白C、蛋白S、纤溶酶原、蛋白Z、总组织因子途径抑制物、凝血酶原片段F1.2和D-二聚体的H_2R和C_2。在根据年龄、血型、性别、吸烟和激素避孕药调整后的一个模型中，发现Lp(A)、低密度脂蛋白、纤维蛋白原、蛋白C和蛋白Z的显著H2 R估计。除了显著的H2 R估计外，c2对纤维蛋白原、蛋白C和蛋白Z的表型变化有显著的影响。对胆固醇和血浆FII、Fv、vWF、抗凝血酶、S蛋白、纤溶酶原和TFP I的水平从9.3%到33.2%有显著的c2效应。我们的研究强调了研究与儿童中风相关的危险因素的遗传变异性和生活方式改变的重要性。
The identification of heritable and environmental factors possibly influencing a condition at risk should be a prerequisite for the search for the proportion of variance attributable for shared environmental effects (c2) modulating the risk of disease. Such epidemiologic approaches in families with a first acute ischemic stroke during early childhood are lacking. Our goal was to estimate the phenotypic variation within lipid concentrations and coagulation factor levels and to estimate the proportions attributable to heritability (h2r) and c2 in pediatric stroke families. Blood samples were collected from 1,002 individuals from 282 white stroke pedigrees. We estimated h2r and c2 for lipoprotein (a) [Lp(a)], cholesterol, high-density lipoprotein, low-density lipoprotein (LDL), fibrinogen, factor (F) II, FV, FVIIIC, von Willebrand factor (vWF), antithrombin, protein C, protein S, plasminogen, protein Z, total tissue factor pathway inhibitor (TFPI), prothrombin fragment F1.2, and D-dimer, using the variance component method in sequential oligogenetic linkage analysis routines. When incorporating h2r and c2 in one model adjusted for age, blood group, sex, smoking, and hormonal contraceptives, significant h2r estimates were found for Lp(a), LDL, fibrinogen, protein C, and protein Z. In addition to the significant h2r estimates, c2 showed a significant effect on phenotypic variation for fibrinogen, protein C, and protein Z. A significant c2 effect was found for cholesterol, and plasma levels of FII, FV, vWF, antithrombin, protein S, plasminogen, and TFPI, ranging from 9.3% to 33.2%. Our research stresses the importance of research on the genetic variability and lifestyle modifications of risk factors associated with pediatric stroke.
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影响因子：
8.3
作者：
McQuillan, AM;Eikelboom, JW;Cole, V
通讯作者：
Cole, V
DOI：
10.1161/01.atv.0000227510.36653.ed
发表时间：
2006-08-01
影响因子：
8.7
作者：
Kreuz, Wolfhart;Stoll, Monika;Nowak-Goettl, Ulrike
通讯作者：
Nowak-Goettl, Ulrike
影响因子：
30.8
作者：
Broeckel, U;Hengstenberg, C;Schunkert, H
通讯作者：
Schunkert, H
DOI：
10.1375/1369052022956
发表时间：
2002-04-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Beekman, M;Heijmans, BT;Boomsma, DI
通讯作者：
Boomsma, DI
影响因子：
168.9
作者：
Ariëns, RAS;de Lange, M;Grant, PJ
通讯作者：
Grant, PJ