Structural and functional cerebral bases of diminished inhibitory control during healthy aging.
Structural and functional cerebral bases of diminished inhibitory control during healthy aging.
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DOI：
10.1002/hbm.24347
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发表时间：
2018-12
影响因子：
4.8
通讯作者：
Li CR
中科院分区：
文献类型：
--
作者：
Hu S;Ide JS;Chao HH;Castagna B;Fischer KA;Zhang S;Li CR
抑制控制或避免不正确反应的能力是一种重要的执行功能，已知会在衰老过程中减弱。影像学研究已经阐明了大脑的变化，可能是这些年龄相关的缺陷。然而，目前尚不清楚结构和功能的变化是否发生在相同的大脑区域，以及是否减少灰质体积（GMV）介导抑制过程中的激活减少。在这里，在149名参与者的样本中，我们使用结构和功能磁共振成像（MRI/fMRI）数据收集的停止信号任务来解决这些问题。个体的反应抑制通过停止信号反应时间（SSRT）来评价。结果表明，年龄与参与者的SSRT延长有关。许多皮质和皮质下区域表现出与年龄相关的GMV减少和激活反应抑制。另一方面，年龄相关的减少抑制控制，指数的SSRT，与共享和不同的形态和功能的变化。基于体素的形态测量表明，与年龄相关的减少GMV在右背外侧前额叶皮层和尾状头，以及双边脑，与延长SSRT。在停止成功与继续成功试验的对比中，年龄与内侧和下额叶皮层以及下顶叶皮层的较低激活相关。此外，减少GMV介导的年龄相关的差异激活内侧前额叶皮层，提供有限的证据结构功能协会。因此，在抑制控制的下降，证明在停止信号任务，表现与共享和不同的结构和功能过程中老化。
Inhibitory control or the ability to refrain from incorrect responses is a critical executive function known to diminish during aging. Imaging studies have elucidated cerebral changes that may underlie these age-related deficits. However, it remains unclear whether the structural and functional changes occur in the same brain regions and whether reduced gray matter volumes (GMV) mediate decreased activation during inhibition. Here, in a sample of 149 participants, we addressed these issues using structural and functional magnetic resonance imaging (MRI/fMRI) data collected of a stop signal task. Individual’s response inhibition was evaluated by the stop signal reaction time (SSRT). The results showed that age was associated with prolonged SSRT across participants. Many cortical and subcortical regions demonstrated age-related reduction in GMV and activation to response inhibition. On the other hand, age-related diminution in inhibitory control, as indexed by the SSRT, was associated with both shared and distinct morphometric and functional changes. Voxel-based morphometry demonstrated age-related reduction in GMV in the right dorsolateral prefrontal cortex and caudate head as well as bilateral insula, in association with prolonged SSRT. In a contrast of stop success vs. go success trials, age was associated with lower activation in the medial and inferior frontal cortex and inferior parietal cortex. Further, reduction in GMV mediated age-related differences in activations only of the medial prefrontal cortex, providing limited evidence for structure function association. Thus, the decline in inhibitory control, as evidenced in the stop signal task, manifest with both shared and distinct structural and functional processes during aging.
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DOI：
10.1016/j.pnpbp.2013.09.001
发表时间：
2014-01-03
影响因子：
5.6
作者：
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通讯作者：
Biswal, Bharat B.
影响因子：
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影响因子：
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
5.7
作者：
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McIntosh, AR