Characterization of Flowing Blood Optical Property Under Various Fibrinogen Levels Using Optical Coherence Tomography
Characterization of Flowing Blood Optical Property Under Various Fibrinogen Levels Using Optical Coherence Tomography
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使用光学相干断层扫描表征不同纤维蛋白原水平下的流动血液光学特性
DOI：
10.1109/tbme.2012.2207899
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发表时间：
2012-07
影响因子：
4.6
通讯作者：
Geng, Jinhai
中科院分区：
文献类型：
--
作者：
Fu, Feifei;Xu, Xiangqun;Geng, Jinhai
研究了利用光学相干断层扫描（OCT）表征人血纤维蛋白原水平的可行性。用红细胞重构三组血液样品：1）磷酸盐缓冲盐水; 2）去除其固有纤维蛋白原并添加商业纤维蛋白原的血浆;和3）具有各种纤维蛋白原水平（0-12 g/L）的天然血浆。从OCT深度-反射率曲线中提取血液的OCT信号斜率（OCTSS）。研究了不同纤维蛋白原浓度下红细胞压积（HCT）和血流量对血液OCTSS的影响。以5 mm/s血流速度的实验结果表明，在HCT为40%时，随着纤维蛋白原浓度的增加，三组的OCTSS均降低，达到一定程度后，即随着纤维蛋白原浓度的增加，OCTSS降低。例如，组1、2和3分别>8、6和4 g/L。第2组的血液在HCT为30%、40%和50%时，在纤维蛋白原浓度分别为0-2、0-6和0-10 g/L的范围内，OCTSS迅速下降。在各纤维蛋白原浓度下，血流速度为2.5mm/s时的OCTSS值均低于血流速度为5 mm/s时的OCTSS值。结论OCTSS与血浆纤维蛋白原浓度具有较强的相关性，可用于诊断人血纤维蛋白原的异常水平。
The feasibility of characterization of human blood fibrinogen levels using optical coherence tomography (OCT) was investigated. Three groups of blood samples were reconstituted of red blood cells: 1) phosphate-buffered saline; 2) plasma with its intrinsic fibrinogen removed and commercial fibrinogen added; and 3) native plasma with various fibrinogen levels (0–12 g/L). OCT signal slope (OCTSS) of blood was extracted from OCT depth-reflectivity profiles. Effects of hematocrit (HCT) and blood flow on OCTSS of the blood under various fibrinogen concentrations were also studied. The results of blood flowing at 5 mm/s showed that OCTSS of all the three groups at HCT of 40% decreases with the increasing fibrinogen concentration up to a certain level, i. e., >8, 6, and 4 g/L for groups 1, 2, and 3, respectively. The blood of group 2 at HCTs of 30%, 40%, and 50% had a rapid decrease in OCTSS in the range of fibrinogen concentration of 0–2, 0–6, and 0–10 g/L, respectively. OCTSS value of blood flowing at 2.5 mm/s was lower than that at 5 mm/s at each fibrinogen concentration. In conclusion, OCTSS has a strong correlation with plasma fibrinogen concentration, and has the potential to identify the abnormal level of human blood fibrinogen.
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影响因子：
7.5
作者：
P. Llamas;A. B. Santos;J. Outeiriño;C. Soto;J. Tomás
通讯作者：
P. Llamas;A. B. Santos;J. Outeiriño;C. Soto;J. Tomás
DOI：
10.1172/jci105836
发表时间：
1968-06
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
H. Schmid-schönbein;P. Gaehtgens;H. Hirsch
通讯作者：
H. Schmid-schönbein;P. Gaehtgens;H. Hirsch
影响因子：
3.5
作者：
Xiangqun Xu;Yeh-Chan Ahn;Zhongping Chen
通讯作者：
Xiangqun Xu;Yeh-Chan Ahn;Zhongping Chen
影响因子：
2.4
作者：
A. Clauss
通讯作者：
A. Clauss
影响因子：
2
作者：
Podoleanu AG
通讯作者：
Podoleanu AG