Higher levels of GATA3 predict better survival in women with breast cancer.
Higher levels of GATA3 predict better survival in women with breast cancer.
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DOI：
10.1016/j.humpath.2010.06.010
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发表时间：
2010-12
期刊：
影响因子：
3.3
通讯作者：
Goodglick, Lee
中科院分区：
文献类型：
--
作者：
Yoon, Nam K.;Maresh, Erin L.;Shen, Dejun;Elshimali, Yahya;Apple, Sophia;Horvath, Steve;Mah, Vei;Bose, Shikha;Chia, David;Chang, Helena R.;Goodglick, Lee
GATA家族成员是参与细胞分化和增殖的锌指转录因子。特别是GATA3对于乳腺成熟是必需的，它的缺失与乳腺癌的发展有关。我们的目标是验证GATA3表达预测乳腺癌患者生存的能力。在242例乳腺癌的高密度组织芯片上分析了GATA3蛋白的表达。我们将GATA3表达与患者预后和临床病理变量联系起来。与正常乳腺组织相比，GATA3在乳腺癌、原位病变和增生性组织中的表达显著增加。GATA3的表达随肿瘤分级的增加而降低。低GATA3表达是所有患者以及雌激素受体阳性亚组或低分级患者疾病相关死亡的重要预测因子。此外，低GATA3表达与肿瘤大小增加和雌激素、孕激素受体阴性相关。GATA3是乳腺癌患者疾病结局的重要预测因子。这一发现在不同的人群中得到了证实。因此，GATA3的表达可作为乳腺癌的预后指标。
The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. GATA3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. Our goal was to validate the ability of GATA3 expression to predict survival in breast cancer patients. Protein expression of GATA3 was analyzed on a high density tissue microarray consisting of 242 cases of breast cancer. We associated GATA3 expression with patient outcomes and clinicopathological variables. Expression of GATA3 was significantly increased in breast cancer, in situ lesions, and hyperplastic tissue compared to normal breast tissue. GATA3 expression decreased with increasing tumor grade. Low GATA3 expression was a significant predictor of disease-related death in all patients, as well as in subgroups of estrogen receptor positive or low grade patients. Additionally, low GATA3 expression correlated with increased tumor size and estrogen and progesterone receptor negativity. GATA3 is an important predictor of disease outcome in breast cancer patients. This finding has been validated in a diverse set of populations. Thus, GATA3 expression has utility as a prognostic indicator in breast cancer.
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