Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data.
Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data.
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DOI：
10.1093/nar/gkaa1006
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发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Gao Y;Shang S;Guo S;Li X;Zhou H;Liu H;Sun Y;Wang J;Wang P;Zhi H;Li X;Ning S;Zhang Y
更新的Lnc 2Cancer 3.0（http：www.bio-bigdata.net/lnc2cancer或http：//bio-bigdata.hrbmu.edu.cn/lnc2cancer）数据库，其中包括与人类癌症相关的实验支持的长非编码RNA（lncRNA）和环状RNA（circRNA）的全面数据。此外，描述了通过高通量RNA测序（RNA-seq）和单细胞RNA-seq（scRNA-seq）分析lncRNA表达的网络工具。Lnc 2Cancer 3.0更新了几个新功能，包括（i）与前一版本相比增加了癌症相关的lncRNA条目。目前的版本包括9254种lncRNA-癌症关联，其中2659种lncRNA和216种癌症亚型。(ii)新增加了1049个实验支持的circRNA-癌症关联，其中743个circRNA和70个癌症亚型。(iii)包括实验支持的癌症相关lncRNA和circRNA的调控机制，涉及microRNA、转录因子（TF）、遗传变异、甲基化和增强子。(iv)实验证实了肿瘤相关lncRNA和circRNA的生物学功能，包括细胞生长、凋亡、自噬、上皮间质转化（EMT）、免疫和编码能力。(v)包括实验支持的癌症相关lncRNA和circRNA在转移、复发、循环、耐药性和预后中的临床相关性。此外，还开发了两种灵活的在线工具，包括RNA-seq和scRNA-seq网络工具，以实现癌症中lncRNA的快速和可定制的分析和可视化。Lnc 2Cancer 3.0是阐明lncRNA，circRNA和癌症之间关系的宝贵资源。
An updated Lnc2Cancer 3.0 (http://www.bio-bigdata.net/lnc2cancer or http://bio-bigdata.hrbmu.edu.cn/lnc2cancer) database, which includes comprehensive data on experimentally supported long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) associated with human cancers. In addition, web tools for analyzing lncRNA expression by high-throughput RNA sequencing (RNA-seq) and single-cell RNA-seq (scRNA-seq) are described. Lnc2Cancer 3.0 was updated with several new features, including (i) Increased cancer-associated lncRNA entries over the previous version. The current release includes 9254 lncRNA-cancer associations, with 2659 lncRNAs and 216 cancer subtypes. (ii) Newly adding 1049 experimentally supported circRNA-cancer associations, with 743 circRNAs and 70 cancer subtypes. (iii) Experimentally supported regulatory mechanisms of cancer-related lncRNAs and circRNAs, involving microRNAs, transcription factors (TF), genetic variants, methylation and enhancers were included. (iv) Appending experimentally supported biological functions of cancer-related lncRNAs and circRNAs including cell growth, apoptosis, autophagy, epithelial mesenchymal transformation (EMT), immunity and coding ability. (v) Experimentally supported clinical relevance of cancer-related lncRNAs and circRNAs in metastasis, recurrence, circulation, drug resistance, and prognosis was included. Additionally, two flexible online tools, including RNA-seq and scRNA-seq web tools, were developed to enable fast and customizable analysis and visualization of lncRNAs in cancers. Lnc2Cancer 3.0 is a valuable resource for elucidating the associations between lncRNA, circRNA and cancer.
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影响因子：
14.9
作者：
Frankish A;Diekhans M;Ferreira AM;Johnson R;Jungreis I;Loveland J;Mudge JM;Sisu C;Wright J;Armstrong J;Barnes I;Berry A;Bignell A;Carbonell Sala S;Chrast J;Cunningham F;Di Domenico T;Donaldson S;Fiddes IT;García Girón C;Gonzalez JM;Grego T;Hardy M;Hourlier T;Hunt T;Izuogu OG;Lagarde J;Martin FJ;Martínez L;Mohanan S;Muir P;Navarro FCP;Parker A;Pei B;Pozo F;Ruffier M;Schmitt BM;Stapleton E;Suner MM;Sycheva I;Uszczynska-Ratajczak B;Xu J;Yates A;Zerbino D;Zhang Y;Aken B;Choudhary JS;Gerstein M;Guigó R;Hubbard TJP;Kellis M;Paten B;Reymond A;Tress ML;Flicek P
通讯作者：
Flicek P
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影响因子：
14.9
作者：
Li S;Li Y;Chen B;Zhao J;Yu S;Tang Y;Zheng Q;Li Y;Wang P;He X;Huang S
通讯作者：
Huang S
影响因子：
8.8
作者：
Frank, Filipp;Kavousi, Nadieh;Ortlund, Eric A.
通讯作者：
Ortlund, Eric A.
miR-184 及其 r.57c > u 人晶状体上皮细胞突变型治疗中 mRNA/circRNA 的全转录组研究
DOI：
10.1016/j.omtn.2017.02.008
发表时间：
2017-06-16
期刊：
Molecular therapy. Nucleic acids
影响因子：
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作者：
Luo Y;Liu S;Yao K
通讯作者：
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影响因子：
14.9
作者：
Ma L;Cao J;Liu L;Du Q;Li Z;Zou D;Bajic VB;Zhang Z
通讯作者：
Zhang Z