LncBook: a curated knowledgebase of human long non-coding RNAs.
LncBook: a curated knowledgebase of human long non-coding RNAs.
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DOI：
10.1093/nar/gky960
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Ma L;Cao J;Liu L;Du Q;Li Z;Zou D;Bajic VB;Zhang Z
长链非编码RNA（lncRNA）在许多重要的生物学过程中具有重要的功能。尽管已知的人类lncRNA的数量急剧增加，但它们的注释很差，这对更好地理解它们的功能意义和阐明它们复杂的功能分子机制提出了巨大挑战。在这里，我们介绍了LncBook（http：//bigd.big.ac.cn/lncbook），这是一个人类lncRNA的策展知识库，其特点是全面收集人类lncRNA，并通过多组学数据整合，功能注释和疾病关联对lncRNA进行系统策展。在目前的版本中，LncBook容纳了大量的270 044个lncRNA，包括1867个特色lncRNA和3762个lncRNA功能关联。它还整合了来自表达，甲基化，基因组变异和lncRNA-miRNA相互作用的丰富的多组学数据。此外，LncBook整合了3772个实验验证的lncRNA-疾病关联，并进一步鉴定了总共97998个与脓疱病相关的lncRNA。总的来说，lncBook致力于人类lncRNA及其相关数据的整合和管理，因此很有希望成为全球研究界的宝贵知识库。
Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number of known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating their complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), a curated knowledgebase of human lncRNAs that features a comprehensive collection of human lncRNAs and systematic curation of lncRNAs by multi-omics data integration, functional annotation and disease association. In the present version, LncBook houses a large number of 270 044 lncRNAs and includes 1867 featured lncRNAs with 3762 lncRNA–function associations. It also integrates an abundance of multi-omics data from expression, methylation, genome variation and lncRNA–miRNA interaction. Also, LncBook incorporates 3772 experimentally validated lncRNA-disease associations and further identifies a total of 97 998 lncRNAs that are putatively disease-associated. Collectively, LncBook is dedicated to the integration and curation of human lncRNAs as well as their associated data and thus bears great promise to serve as a valuable knowledgebase for worldwide research communities.
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DOI：
10.1126/science.aah7111
发表时间：
2017-01-06
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Liu SJ;Horlbeck MA;Cho SW;Birk HS;Malatesta M;He D;Attenello FJ;Villalta JE;Cho MY;Chen Y;Mandegar MA;Olvera MP;Gilbert LA;Conklin BR;Chang HY;Weissman JS;Lim DA
通讯作者：
Lim DA
starBase v2.0：从大规模 CLIP-Seq 数据中解码 miRNA-ceRNA、miRNA-ncRNA 和蛋白质-RNA 相互作用网络
影响因子：
14.9
作者：
Li JH;Liu S;Zhou H;Qu LH;Yang JH
通讯作者：
Yang JH
影响因子：
14.9
作者：
The RNAcentral Consortium;Petrov AI;Kay SJE;Kalvari I;Howe KL;Gray KA;Bruford EA;Kersey PJ;Cochrane G;Finn RD;Bateman A;Kozomara A;Griffiths-Jones S;Frankish A;Zwieb CW;Lau BY;Williams KP;Chan PP;Lowe TM;Cannone JJ;Gutell R;Machnicka MA;Bujnicki JM;Yoshihama M;Kenmochi N;Chai B;Cole JR;Szymanski M;Karlowski WM;Wood V;Huala E;Berardini TZ;Zhao Y;Chen R;Zhu W;Paraskevopoulou MD;Vlachos IS;Hatzigeorgiou AG;Ma L;Zhang Z;Puetz J;Stadler PF;McDonald D;Basu S;Fey P;Engel SR;Cherry JM;Volders PJ;Mestdagh P;Wower J;Clark MB;Quek XC;Dinger ME
通讯作者：
Dinger ME
影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium