Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model.
Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model.
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DOI：
10.1111/dgd.12351
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Guo S
中科院分区：
文献类型：
--
作者：
Oltrabella F;Melgoza A;Nguyen B;Guo S
内源性大麻素系统（eCBs）以植物大麻命名，由大麻素受体、内源性配体（内源性大麻素）、参与这些配体生物合成和降解的酶以及这些配体的假定转运体组成。在许多脊椎动物模型的早期胚胎阶段已经检测到ECBs蛋白和小分子。因此，大麻素受体和内源性以及外源性大麻素影响许多脊椎动物物种的发育和行为。了解脑脊液的确切作用机制将为阐明脊椎动物的发育提供宝贵的指导，也将有助于描述大麻对成年期健康、认知和执行功能的影响。在这里，我们回顾了脑脊液在脊椎动物发育中的作用，重点关注斑马鱼模型。由于对斑马鱼的eCBs知之甚少，我们提供了斑马鱼在发育期间和成年组织类型中eCBs基因表达谱的新数据。我们还强调了未来研究的令人兴奋的领域，包括脑脊液的突触调节，其在奖励和成瘾中的作用，以及在神经系统发育和可塑性中的作用。斑马鱼正常的肝功能似乎依赖于正常的、功能正常的ecb。
The endocannabinoid system (eCBs), named after the plant Cannabis sativa, comprises cannabinoid receptors, endogenous ligands known as “endocannabinoids”, and enzymes involved in the biosynthesis and degradation of these ligands, as well as putative transporters for these ligands. ECBs proteins and small molecules have been detected in early embryonic stages of many vertebrate models. As a result, cannabinoid receptors and endogenous as well as exogenous cannabinoids influence development and behavior in many vertebrate species. Understanding the precise mechanisms of action for the eCBs will provide an invaluable guide towards elucidation of vertebrate development and will also help delineate how developmental exposure to marijuana might impact health and cognitive and executive functioning in adulthood. Here we review the developmental roles of the eCBs in vertebrates, focusing our attention on the zebrafish model. Since little is known regarding the eCBs in zebrafish, we provide new data on the expression profiles of eCBs genes during development and in adult tissue types of this model organism. We also highlight exciting areas for future investigations, including the synaptic regulation of eCBs, its role in reward and addiction, and in nervous system development and plasticity. Proper liver function in zebrafish appears to be dependent on a normal, functioning eCBs.
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影响因子：
2.7
作者：
Ahmed, Mostafa H.;Kellogg, Glen E.;Zhang, Yan
通讯作者：
Zhang, Yan
影响因子：
3.5
作者：
Beatrice, M;Gabriella, M;Oliana, C
通讯作者：
Oliana, C
人体免疫组织和白细胞亚群中枢和外周大麻素受体的表达
DOI：
10.1111/j.1432-1033.1995.tb20780.x
发表时间：
1995-08-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
GALIEGUE, S;MARY, S;CASELLAS, P
通讯作者：
CASELLAS, P
影响因子：
5.3
作者：
Diaz-Alonso, Javier;Aguado, Tania;Galve-Roperh, Ismael
通讯作者：
Galve-Roperh, Ismael
影响因子：
4.5
作者：
Connors, Kristin A.;Valenti, Theodore W.;Lawless, Kelly;Sackerman, James;Onaivi, Emmanuel S.;Brooks, Bryan W.;Gould, Georgianna G.
通讯作者：
Gould, Georgianna G.