Shedding of pandemic (H1N1) 2009 virus among health care personnel, Seattle, Washington, USA.
Shedding of pandemic (H1N1) 2009 virus among health care personnel, Seattle, Washington, USA.
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DOI：
10.3201/eid1704.100866
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发表时间：
2011-04
影响因子：
11.8
通讯作者：
Duchin JS
中科院分区：
文献类型：
--
作者：
Kay M;Zerr DM;Englund JA;Cadwell BL;Kuypers J;Swenson P;Kwan-Gett TS;Bell SL;Duchin JS
美国疾病控制与预防中心（CDC）建议感染2009年H1N1流感病毒的医护人员（HCP）在不使用退烧药的情况下，直到发烧消退24小时后才能工作。在流感爆发期间，我们检查了感染HCP的病毒脱落和发烧之间的关系。参与者每天记录体温，并在症状出现后两周内提供洗鼻标本。采用PCR法和培养法对标本进行检测。当他们符合CDC的复工标准时，16名HCP中有12名（75%）（95%置信区间为48%-93%）经PCR检测出病毒，9名（56%）（95%置信区间为30%-80%）经培养检测出病毒。发热与脱落时间无关（p = 0.65）。即使符合疾病预防控制中心的排除指南，HCP也可能会传播病毒。需要进一步的研究来阐明病毒脱落、症状和传染性之间的关系。
The Centers for Disease Control and Prevention (CDC) recommends that health care personnel (HCP) infected with pandemic influenza (H1N1) 2009 virus not work until 24 hours after fever subsides without the use of antipyretics. During an influenza outbreak, we examined the association between viral shedding and fever among infected HCP. Participants recorded temperatures daily and provided nasal wash specimens for 2 weeks after symptom onset. Specimens were tested by using PCR and culture. When they met CDC criteria for returning to work, 12 of 16 HCP (75%) (95% confidence interval 48%–93%) had virus detected by PCR, and 9 (56%) (95% confidence interval 30%–80%) had virus detected by culture. Fever was not associated with shedding duration (p = 0.65). HCP might shed virus even when meeting CDC exclusion guidelines. Further research is needed to clarify the association between viral shedding, symptoms, and infectiousness.
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DOI：
10.1056/nejmoa0905498
发表时间：
2009-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cauchemez S;Donnelly CA;Reed C;Ghani AC;Fraser C;Kent CK;Finelli L;Ferguson NM
通讯作者：
Ferguson NM
影响因子：
9.4
作者：
Kuypers, Jane;Wright, Nancy;Morrow, Rhoda
通讯作者：
Morrow, Rhoda
影响因子：
8.8
作者：
Barenfanger, J;Drake, C;Guttman, K
通讯作者：
Guttman, K
影响因子：
8.8
作者：
Kaiser, L;Briones, MS;Hayden, FG
通讯作者：
Hayden, FG
DOI：
10.1086/648508
发表时间：
2009-12-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Crum-Cianflone NF;Blair PJ;Faix D;Arnold J;Echols S;Sherman SS;Tueller JE;Warkentien T;Sanguineti G;Bavaro M;Hale BR
通讯作者：
Hale BR