Clinical and epidemiologic characteristics of an outbreak of novel H1N1 (swine origin) influenza A virus among United States military beneficiaries.
Clinical and epidemiologic characteristics of an outbreak of novel H1N1 (swine origin) influenza A virus among United States military beneficiaries.
复制标题
DOI：
10.1086/648508
复制
发表时间：
2009-12-15
期刊：
影响因子：
--
通讯作者：
Hale BR
中科院分区：
文献类型：
--
作者：
Crum-Cianflone NF;Blair PJ;Faix D;Arnold J;Echols S;Sherman SS;Tueller JE;Warkentien T;Sanguineti G;Bavaro M;Hale BR
2009年3月发现了一种新的猪源甲型H1N1流感病毒，随后引发了全球疫情。圣地亚哥地区是新出现的大流行的早期焦点。我们描述了这种新型毒株在军事人群中的临床和流行病学特征，以帮助未来的疫情预防和控制工作。我们对圣地亚哥县在96,258名当地美军受益者中诊断出的新型H1N1病毒感染进行了流行病学评估。结构化的军事医疗系统使人们能够获得关于H1N1病毒在人群中感染的影响的准确流行病学信息。用实时逆转录聚合酶链式反应(RRT-PCR)对该新型H1N1病毒进行了鉴定。从2009年4月21日至5月8日，761名患者出现流感样疾病并接受了RRT-PCR检测。在这些患者中，97人确诊为新型H1N1病毒感染，发病率为101例/10万人。感染H1N1病毒的H1N1患者的中位年龄为21岁(四分位数范围为15-25岁)。发烧是H1N1病毒感染患者的普遍症状；其他症状包括咳嗽(96%的患者出现)、肌肉痛或关节痛(57%)和喉咙痛(51%)。我们的68名患者(70%)与另一名确诊患者有可识别的流行病学联系。最大的H1N1病毒感染聚集性病例发生在一艘海军舰艇上，涉及402名船员中的32名(8%)；二次侵袭率为6%-14%。与RRT-PCR相比，此次暴发期间使用的快速流感检测的敏感度为51%，特异度为98%。仅1名患者入院治疗，无死亡病例。一种新的甲型H1N1流感病毒在圣地亚哥县的军事受益者中造成了重大疫情，包括一艘海军舰艇上的大量病例。这里描述的暴发主要影响青少年和年轻人，并导致了一种没有后遗症的发热性疾病。
A novel swine-origin influenza A (H1N1) virus was identified in March 2009 and subsequently caused worldwide outbreaks. The San Diego region was an early focal point of the emerging pandemic. We describe the clinical and epidemiologic characteristics of this novel strain in a military population to assist in future outbreak prevention and control efforts. We performed an epidemiologic evaluation of novel H1N1 virus infections diagnosed in San Diego County among 96,258 local US military beneficiaries. The structured military medical system afforded the ability to obtain precise epidemiologic information on the impact on H1N1 virus infection in a population. The novel H1N1 virus was confirmed using real-time reverse transcriptase polymerase chain reaction (rRT-PCR). From 21 April through 8 May 2009, 761 patients presented with influenza-like illness and underwent rRT-PCR testing. Of these patients, 97 had confirmed novel H1N1 virus infection, with an incidence rate of 101 cases per 100,000 persons. The median age of H1N1 patients with H1N1 virus infection was 21 years (interquartile range, 15–25 years). Fever was a universal symptom in patients with H1N1 virus infection; other symptoms included cough (present in 96% of patients), myalgia or arthralgia (57%), and sore throat (51%). Sixty-eight (70%) of our patients had an identifiable epidemiologic link to another confirmed patient. The largest cluster of cases of H1N1 virus infection occurred on a Navy ship and involved 32 (8%) of 402 crew members; the secondary attack rate was 6%–14%. The rapid influenza testing that was used during this outbreak had a sensitivity of 51% and specificity of 98%, compared with rRT-PCR. Only 1 patient was hospitalized, and there were no deaths. A novel H1N1 influenza A virus caused a significant outbreak among military beneficiaries in San Diego County, including a significant cluster of cases onboard a Navy ship. The outbreak described here primarily affected adolescents and young adults and resulted in a febrile illness without sequelae.
登录
查看更多内容
影响因子：
6.4
作者：
Morens, David M.;Fauci, Anthony S.
通讯作者：
Fauci, Anthony S.
影响因子：
6.4
作者：
DOWDLE, WR;HATTWICK, MAW
通讯作者：
HATTWICK, MAW
影响因子：
3.9
作者：
Lessler, Justin;Cummings, Derek A. T.;Burke, Donald S.
通讯作者：
Burke, Donald S.
影响因子：
11.8
作者：
Monto, Arnold S.
通讯作者：
Monto, Arnold S.
影响因子：
5.5
作者：
Viboud, Cecile;Tam, Theresa;Simonsen, Lone
通讯作者：
Simonsen, Lone