Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
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DOI：
10.3390/nu13093132
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发表时间：
2021-09-08
期刊：
影响因子：
5.9
通讯作者：
Jenab M
中科院分区：
文献类型：
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作者：
Aglago EK;Mayén AL;Knaze V;Freisling H;Fedirko V;Hughes DJ;Jiao L;Eriksen AK;Tjønneland A;Boutron-Ruault MC;Rothwell JA;Severi G;Kaaks R;Katzke V;Schulze MB;Birukov A;Palli D;Sieri S;Santucci de Magistris M;Tumino R;Ricceri F;Bueno-de-Mesquita B;Derksen JWG;Skeie G;Gram IT;Sandanger T;Quirós JR;Luján-Barroso L;Sánchez MJ;Amiano P;Chirlaque MD;Gurrea AB;Johansson I;Manjer J;Perez-Cornago A;Weiderpass E;Gunter MJ;Heath AK;Schalkwijk CG;Jenab M
膳食晚期糖基化终产物（dAGEs）通过促进结肠上皮的炎症、代谢功能障碍和氧化应激而被假设与结直肠癌（CRC）的高风险相关。然而，来自前瞻性队列研究的证据是稀缺的和不确定的。我们在欧洲癌症与营养前瞻性研究（EPIC）中评估了与dAGEs摄入相关的CRC风险。通过与详细公布的欧洲食物组成数据库匹配，估计了450，111名参与者（中位随访时间= 13年，6162例CRC病例）的三种主要dAGE的饮食摄入量：Nε-羧基甲基赖氨酸（CML）、Nε-羧基乙基赖氨酸（CEL）和Nδ-（5-氢-5-甲基-4-咪唑啉-2-基）-鸟氨酸（MG-H1）。使用多变量校正的考克斯回归模型计算dAGE与CRC相关性的风险比（HR）和95%置信区间（CI）。观察到CML（HR比较极端五分位数：HRQ5vs.Q1 = 0.92，95%CI = 0.85-1.00）和MG-H1（HRQ5vs.Q1 = 0.92，95%CI = 0.85-1.00）与CRC风险呈反向相关，但CEL（HRQ5vs.Q1 = 0.97，95%CI = 0.89-1.05）未观察到相关性。这种关联在性别或肿瘤的解剖位置上没有差异。与最初的假设相反，我们的研究结果表明dAGEs和CRC风险之间呈负相关。需要更多的研究来验证这些发现，并更好地区分dAGEs与内源性AGEs及其前体化合物在CRC发展中的作用。
Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
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DOI：
10.5455/aim.2015.23.90-96
发表时间：
2015-04
期刊：
Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH
影响因子：
--
作者：
Fatchiyah F;Hardiyanti F;Widodo N
通讯作者：
Widodo N
DOI：
10.1136/bmj.d6617
发表时间：
2011-11-10
期刊：
BMJ (Clinical research ed.)
影响因子：
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作者：
Aune D;Chan DS;Lau R;Vieira R;Greenwood DC;Kampman E;Norat T
通讯作者：
Norat T
影响因子：
8.8
作者：
Nicolas, Genevieve;Witthoft, Cornelia M.;Slimani, Nadia
通讯作者：
Slimani, Nadia
影响因子：
2.6
作者：
Chen, Liang;Duan, Zhigang;Jiaoa, Li
通讯作者：
Jiaoa, Li
影响因子：
6.1
作者：
Hellwig, Michael;Bunzel, Diana;Henle, Thomas
通讯作者：
Henle, Thomas