Genotype to phenotype: a complex problem.
Genotype to phenotype: a complex problem.
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DOI：
10.1126/science.1189015
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发表时间：
2010-04-23
期刊：
影响因子：
--
通讯作者：
Boone C
中科院分区：
文献类型：
--
作者：
Dowell RD;Ryan O;Jansen A;Cheung D;Agarwala S;Danford T;Bernstein DA;Rolfe PA;Heisler LE;Chin B;Nislow C;Giaever G;Phillips PC;Fink GR;Gifford DK;Boone C
我们生成了高分辨率的全基因组序列，并单独删除了与参考菌株S288c密切相关的酿酒糖酵母菌Σ1278b的5100个基因。类似于人类个体之间的差异，Σ1278b和S288c平均每千碱基有3.2个单核苷酸多态性。对缺失突变表型的全基因组比较确定了菌株条件必需的基因子集，包括Σ1278b特有的44个必需基因和S288c特有的13个必需基因。遗传分析表明，条件表型通常由复杂的遗传相互作用控制，取决于多个背景特异性修饰因子。我们的综合分析表明，一组复杂修饰的存在往往是个体之间表型差异的基础。
We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Σ1278b, aSaccharomyces cerevisiaestrain closely related to reference strain S288c. Similar to the variation between human individuals, Σ1278b and S288c average 3.2 single-nucleotide polymorphisms per kilobase. A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were conditionally essential by strain, including 44 essential genes unique to Σ1278b and 13 unique to S288c. Genetic analysis indicates the conditional phenotype was most often governed by complex genetic interactions, depending on multiple background-specific modifiers. Our comprehensive analysis suggests that the presence of a complex set of modifiers will often underlie the phenotypic differences between individuals.
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稀有变体会产生整个基因组的关联。
影响因子：
9.8
作者：
Dickson SP;Wang K;Krantz I;Hakonarson H;Goldstein DB
通讯作者：
Goldstein DB
亚洲个体的二倍体基因组序列
影响因子：
64.8
作者：
Wang, Jun;Wang, Wei;Li, Ruiqiang;Li, Yingrui;Tian, Geng;Goodman, Laurie;Fan, Wei;Zhang, Junqing;Li, Jun;Zhang, Juanbin;Guo, Yiran;Feng, Binxiao;Li, Heng;Lu, Yao;Fang, Xiaodong;Liang, Huiqing;Du, Zhenglin;Li, Dong;Zhao, Yiqing;Hu, Yujie;Yang, Zhenzhen;Zheng, Hancheng;Hellmann, Ines;Inouye, Michael;Pool, John;Yi, Xin;Zhao, Jing;Duan, Jinjie;Zhou, Yan;Qin, Junjie;Ma, Lijia;Li, Guoqing;Yang, Zhentao;Zhang, Guojie;Yang, Bin;Yu, Chang;Liang, Fang;Li, Wenjie;Li, Shaochuan;Li, Dawei;Ni, Peixiang;Ruan, Jue;Li, Qibin;Zhu, Hongmei;Liu, Dongyuan;Lu, Zhike;Li, Ning;Guo, Guangwu;Zhang, Jianguo;Ye, Jia;Fang, Lin;Hao, Qin;Chen, Quan;Liang, Yu;Su, Yeyang;San, A.;Ping, Cuo;Yang, Shuang;Chen, Fang;Li, Li;Zhou, Ke;Zheng, Hongkun;Ren, Yuanyuan;Yang, Ling;Gao, Yang;Yang, Guohua;Li, Zhuo;Feng, Xiaoli;Kristiansen, Karsten;Wong, Gane Ka-Shu;Nielsen, Rasmus;Durbin, Richard;Bolund, Lars;Zhang, Xiuqing;Li, Songgang;Yang, Huanming;Wang, Jian
通讯作者：
Wang, Jian
DOI：
10.1126/science.1180823
发表时间：
2010-01-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costanzo M;Baryshnikova A;Bellay J;Kim Y;Spear ED;Sevier CS;Ding H;Koh JL;Toufighi K;Mostafavi S;Prinz J;St Onge RP;VanderSluis B;Makhnevych T;Vizeacoumar FJ;Alizadeh S;Bahr S;Brost RL;Chen Y;Cokol M;Deshpande R;Li Z;Lin ZY;Liang W;Marback M;Paw J;San Luis BJ;Shuteriqi E;Tong AH;van Dyk N;Wallace IM;Whitney JA;Weirauch MT;Zhong G;Zhu H;Houry WA;Brudno M;Ragibizadeh S;Papp B;Pál C;Roth FP;Giaever G;Nislow C;Troyanskaya OG;Bussey H;Bader GD;Gingras AC;Morris QD;Kim PM;Kaiser CA;Myers CL;Andrews BJ;Boone C
通讯作者：
Boone C
影响因子：
64.8
作者：
Giaever, G;Chu, AM;Johnston, M
通讯作者：
Johnston, M
DOI：
10.1126/science.1149504
发表时间：
2007-10-19
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Korbel JO;Urban AE;Affourtit JP;Godwin B;Grubert F;Simons JF;Kim PM;Palejev D;Carriero NJ;Du L;Taillon BE;Chen Z;Tanzer A;Saunders AC;Chi J;Yang F;Carter NP;Hurles ME;Weissman SM;Harkins TT;Gerstein MB;Egholm M;Snyder M
通讯作者：
Snyder M