Reliable assessment of lower limb motor representations with fMRI: use of a novel MR compatible device for real-time monitoring of ankle, knee and hip torques.
Reliable assessment of lower limb motor representations with fMRI: use of a novel MR compatible device for real-time monitoring of ankle, knee and hip torques.
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DOI：
10.1016/j.neuroimage.2008.07.001
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发表时间：
2008-10-15
期刊：
影响因子：
5.7
通讯作者：
Dobkin BH
中科院分区：
文献类型：
--
作者：
Newton JM;Dong Y;Hidler J;Plummer-D'Amato P;Marehbian J;Albistegui-Dubois RM;Woods RP;Dobkin BH
本研究描述了一种新型的磁共振成像（MRI）兼容系统的使用，能够在健康志愿者的功能性MRI（fMRI）测试过程中实时测量等长踝关节，膝关节和髋关节扭矩。在两个时间点研究了三种等长扭矩-踝关节背屈，踝关节跖屈和膝关节伸展的运动表征。检查了运动表现的可靠性和跨会话的脑活动的fMRI衍生的措施。可再现的运动表现，观察到的每一个任务，所要求的幅度的扭矩，视觉反馈的协助下，产生在相关的关节具有良好的准确性，无论是在两个会议。在所有任务中，在中央旁小叶的左侧初级感觉运动皮层（SM 1）和次级运动区观察到显著的血氧水平依赖性（BOLD）信号增加。在这些领域内有大量的重叠的电机表示，虽然差异激活观察SM 1，更大的激活下中央旁小叶在膝关节伸展比踝关节任务。此外，BOLD信号减少，观察到双边SM 1内的手旋钮区域的所有任务。在组水平上未发现主要会话相关影响。观察到高组内相关系数的t值的体素在皮质运动区的每种收缩类型的个人，这表明fMRI衍生的活动跨时间点是可靠的。这些发现支持了在下肢功能的系列研究中使用该装置。
This study describes the use of a novel magnetic resonance imaging (MRI) compatible system capable of measuring isometric ankle, knee and hip joint torques in real-time during functional MRI (fMRI) testing in healthy volunteers. The motor representations of three isometric torques - ankle dorsiflexion, ankle plantarflexion and knee extension – were studied at two time points. The reliability of motor performance and fMRI-derived measures of brain activity across sessions was examined. Reproducible motor performance was observed for each of the tasks; torques of the requested amplitude, assisted by visual feedback, were generated at the relevant joint with good accuracy, both within and across the two sessions. Significant blood oxygen level dependent (BOLD) signal increases were observed in left primary sensorimotor cortex (SM1) in the paracentral lobule and in secondary motor areas for all tasks. Within these areas there was substantial overlap of the motor representations though differential activation was observed in SM1, with greater activation of inferior paracentral lobule during knee extension than for either ankle task. Also, BOLD signal decreases were observed bilaterally within SM1 in the hand knob region for all tasks. No major session related effects were identified at the group level. High intraclass correlation coefficients were observed for t-values of voxels in cortical motor areas for each contraction type for individuals, suggesting that fMRI-derived activity across time points was reliable. These findings support the use of this apparatus in serial studies of lower limb function.
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DOI：
10.1109/tnsre.2007.907689
发表时间：
2007-12-01
影响因子：
4.9
作者：
Hidler, Joseph M.;Carroll, Marti;Federovich, Elissa H.
通讯作者：
Federovich, Elissa H.
影响因子：
2.9
作者：
Borroni, P;Cerri, G;Baldissera, F
通讯作者：
Baldissera, F
影响因子：
5.7
作者：
Eickhoff, Simon B.;Heim, Stefan;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
2
作者：
Ciccarelli, O;Toosy, AT;Thompson, AJ
通讯作者：
Thompson, AJ
影响因子：
5.7
作者：
Debaere, F;Swinnen, SP;Duysens, J
通讯作者：
Duysens, J