Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients.
Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients.
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肿瘤浸润肥大细胞预测胆道癌患者的预后和吉西他滨辅助化疗的益处
DOI：
10.1186/s12885-018-4220-1
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发表时间：
2018-03-21
期刊：
影响因子：
3.8
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Bo X;Wang J;Suo T;Ni X;Liu H;Shen S;Li M;Wang Y;Liu H;Xu J
最近的研究报道TIMs在肿瘤进展或消退中起重要作用，但TIMs在胆道癌中的作用尚不清楚。本研究旨在探讨肿瘤浸润肥大细胞（TIMs）对胆道肿瘤术后患者预后的价值及其对吉西他滨辅助化疗（ACT）获益的影响。方法对中山医院250例胆囊癌（GBC）和肝外胆管癌（EBDC）患者进行胰蛋白酶免疫组化染色。分别分析TIMs与临床病理因素及术后预后的关系。结果高TIMs浸润与延长总生存期（OS）显著相关。此外，多变量分析表明TNM分期和TIMs是OS的独立预后因素。在发现和验证队列中，高TIMs浸润的患者似乎明显受益于基于吉西他滨的ACT。Spearman分析发现TIMs浸润与抗肿瘤CD8+ T细胞呈正相关。结论tims浸润是GBC和EBDC患者独立的预后有利因素，可以更好地对不同预后的患者进行分层，预测吉西他滨基础ACT治疗的获益。
BackgroundRecent studies have reported TIMs play an important role in tumors progression or regression, but the effect of TIMs in biliary tract cancer remains unclear. The aim of this study is to investigate the prognostic value of tumor infiltrating mast cells (TIMs) and its influence on gemcitabine-based adjuvant chemotherapy (ACT) benefits in biliary tract cancer patients after surgery.MethodsTIMs were evaluated by immunohistochemical staining of tryptase in 250 patients with resected gallbladder carcinoma (GBC) or extrahepatic bile duct carcinoma (EBDC) from Zhongshan Hospital. The relationships between TIMs and clinicopathological factors and postoperative prognosis were analyzed respectively.ResultsHigh TIMs infiltration was significantly correlated with prolonged overall survival (OS). Furthermore, multivariate analysis indicated TNM stage and TIMs as independent prognostic factors for OS. Patients with high TIMs infiltration appeared to significantly benefit from Gemcitabine-based ACT in the discovery and validation cohorts. Spearman analysis identified that TIMs infiltration were positively correlated with anti-tumor CD8+ T cells.ConclusionTIMs infiltration is an independent favorable prognostic factor in GBC and EBDC patients, which could better stratify patients with different prognosis and predict benefit from gemcitabine-based ACT.
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影响因子：
3.8
作者：
Rajput, Ashish B.;Turbin, Dmitry A.;Cheang, Maggie C. U.;Voduc, David K.;Leung, Sam;Gelmon, Karen A.;Gilks, C. Blake;Huntsman, David G.
通讯作者：
Huntsman, David G.
肿瘤微环境中的肥大细胞促进了胰腺导管腺癌的体内生长。
DOI：
10.1158/1078-0432.ccr-11-0607
发表时间：
2011-11-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Chang DZ;Ma Y;Ji B;Wang H;Deng D;Liu Y;Abbruzzese JL;Liu YJ;Logsdon CD;Hwu P
通讯作者：
Hwu P
影响因子：
4.4
作者：
Oldford, Sharon A.;Haidl, Ian D.;Marshall, Jean S.
通讯作者：
Marshall, Jean S.
影响因子：
3.1
作者：
Andersen, Maja D.;Kamper, Peter;d'Amore, Francesco
通讯作者：
d'Amore, Francesco
影响因子：
5.6
作者：
Ammendola M;Marech I;Sammarco G;Zuccalà V;Luposella M;Zizzo N;Patruno R;Crovace A;Ruggieri E;Zito AF;Gadaleta CD;Sacco R;Ranieri G
通讯作者：
Ranieri G