Endocrinology of Pregnancy and Parturition
Endocrinology of Pregnancy and Parturition
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妊娠和分娩内分泌学
DOI：
--
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
P. Macdonald
中科院分区：
文献类型：
--
作者：
M. Casey;P. Macdonald
在过去的二十年里，哺乳动物妊娠和分娩的内分泌学研究取得了很大进展。有趣的是，哺乳动物物种中最完整定义的妊娠内分泌生理学是人类。而且，女性怀孕期间发生的内分泌变化是哺乳动物生理学或病理生理学中最显着的变化之一。例如，考虑以下情况：在妊娠期或近期，每天产生75至125 mg雌激素，250至600 mg孕酮，1至2 mg醛固酮和3至12 mg脱氧皮质酮。妊娠期间血浆肾素、血管紧张素原和血管紧张素II水平也显著升高;妊娠期间产生大量蛋白质激素，如绒毛膜促性腺激素、胎盘催乳素、绒毛膜促肾上腺皮质激素、绒毛膜促甲状腺激素等。例如，在一个实施例中，表皮生长因子、转化生长因子和免疫激素剂，e.例如，在一个实施例中，白细胞介素-1和集落刺激因子，在与劳动有关的事件。2所有的研究人员都同意，母亲和胎儿适应这种独特的激素环境是深刻的。许多（如果不是所有的话）研究人员也提出了一种或多种激素，类固醇和蛋白质在协调一系列事件中的作用，这些事件有助于维持妊娠并导致分娩的及时发生和成功分娩。
Much progress has been recorded in the study of the endocrinology of pregnancy and parturition in mammalian species in the past two decades. Interestingly, the most completely defined endocrine physiology of pregnancy among mammalian species is that of the human. And, the endocrine changes that occur during pregnancy in women are among the most remarkable known in mammalian physiology or pathophysiology. Consider, for example, the following: In pregnant women at or near term, 75 to 125 mg of estrogen, 250 to 600 mg of progesterone, 1 to 2 mg of aldosterone, and 3 to 12 mg of deoxycorticosterone are produced each day. There also are phenomenal increases in the levels of plasma renin, angiotensinogen, and angiotensin II during pregnancy; and enormous amounts of protein hormones such as chorionic gonadotropin, placental lactogen, chorionic ACTH, chorionic thyrotropin, and others are produced during pregnancy.1 But more than that, recent evidence is supportive of a role for growth factors, e. g., epidermal growth factor, transforming growth factors, and immunohormonal agents, e. g., interleukin-1 and colony-stimulating factors, in the events that are associated with labor.2 All investigators agree that maternal and fetal adaptations to this distinctive hormonal milieu are profound. And many if not all investigators also propose a role for one or a number of hormones, steroid and protein, in the coordinated set of events that facilitate the maintenance of pregnancy and lead to the timely onset of labor and successful parturition.
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纯合子家族性低β脂蛋白血症患者妊娠期间的内分泌变化。
DOI：
10.1056/nejm198602273140906
发表时间：
1986
期刊：
The New England journal of medicine
影响因子：
--
作者：
ParkerJr,CR;Illingworth,DR;Bissonnette,J;Carr,BR
通讯作者：
Carr,BR
DOI：
10.1172/jci110471
发表时间：
1982
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
MacDonald,PC;Cutrer,S;MacDonald,SC;Casey,ML;ParkerJr,CR
通讯作者：
ParkerJr,CR
羊胎盘芳香酶：芳香酶抑制剂的活性水平、动力学特征和作用的研究。
DOI：
10.1016/0022-4731(87)90371-2
发表时间：
1987
期刊：
Journal of steroid biochemistry
影响因子：
--
作者：
France,JT;Mason,JI;Magness,RR;Murry,BA;Rosenfeld,CR
通讯作者：
Rosenfeld,CR
人类分娩的开始。
影响因子：
9.8
作者：
Okita,JR;MacDonald,PC;Johnston,JM
通讯作者：
Johnston,JM
影响因子：
5.8
作者：
CARR, BR;SIMPSON, ER
通讯作者：
SIMPSON, ER