Global breast cancer incidence and mortality trends by region, age-groups, and fertility patterns.
Global breast cancer incidence and mortality trends by region, age-groups, and fertility patterns.
复制标题
DOI：
10.1016/j.eclinm.2021.100985
复制
发表时间：
2021-08
影响因子：
15.1
通讯作者：
Terry MB
中科院分区：
文献类型：
--
作者：
Lima SM;Kehm RD;Terry MB
乳腺癌（BC）在全球范围内一直在增加，但目前尚不清楚是否在所有年龄组和地区都出现了这种增加，以及发病率的变化是否主要归因于生育率的下降。我们调查了1990年至2017年全球和各地区BC发病率和死亡率的年龄特异性趋势，并评估了发病率趋势是否由生育率下降解释。我们使用国家级数据，按地区和年龄组研究了1990年至2017年BC发病率和死亡率的趋势。使用线性混合模型从年基线模型估计年龄特异性发病率，并与生育率调整模型的发病率进行比较。全球BC死亡率总体每年增加0.23%（95% CI=0.20，0.25），50岁以下和70岁及以上年龄组以及7个区域中的5个区域的死亡率在统计学上显著增加。全球BC发病率总体每年增加1.44%（95% CI=1.42，1.47），所有年龄组和7个地区中的6个地区均出现统计学显著性增加。在调整生育率后，所有年龄组和7个地区中的6个地区的发病率年百分比变化（APC）仍具有统计学显著性（APC=0.84，95% CI=0.81，0.88）。在大多数年龄组和地区，BC死亡率在全球范围内都有所增加。在全球范围内，所有年龄组的BC发病率都有所上升，50岁以下妇女的发病率最高;即使考虑到生育率下降，大多数区域的发病率仍在上升。乳腺癌研究基金会和国家癌症研究所。
Breast cancer (BC) has been increasing globally, though it is unclear whether the increases are seen across all age groups and regions and whether changes in rates can be primarily attributed to decreasing fertility rates. We investigated age-specific trends in BC incidence and mortality from 1990 to 2017, worldwide and by region, and evaluated whether incidence trends are explained by decreases in fertility. We used country-level data to examine trends in BC incidence and mortality rates from 1990 to 2017 by region and age group. Linear mixed models were used to estimate age-specific rates from baseline models of year and were compared to fertility-adjusted models for incidence. The global BC mortality rate increased overall by 0.23% per year (95% CI=0.20, 0.25), with statistically significant increases in the under 50 and 70 and over age groups, and in 5 out of 7 regions. The global BC incidence rate increased overall by 1.44% per year (95% CI=1.42, 1.47), with statistically significant increases in all age groups, and in 6 out of 7 regions. After adjusting for fertility, the incidence annual percent change (APC) remained statistically significant (APC=0.84, 95% CI=0.81, 0.88), in all age groups, and in 6 of 7 regions. The global increase in BC mortality is seen in most age groups and regions. The global increase in BC incidence is seen in all age groups and is highest in women under 50; increases remained in most regions even after considering declining fertility rates. Breast Cancer Research Foundation and National Cancer Institute.
登录
查看更多内容
DOI：
10.1177/1178223417752677
发表时间：
2018
期刊：
Breast cancer : basic and clinical research
影响因子：
--
作者：
Rivera-Franco MM;Leon-Rodriguez E
通讯作者：
Leon-Rodriguez E
影响因子：
3.8
作者：
DeSantis, Carol E.;Bray, Freddie;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
DOI：
10.1186/s40880-018-0308-x
发表时间：
2018-07-03
期刊：
Cancer communications (London, England)
影响因子：
--
作者：
Gu X;Zheng R;Xia C;Zeng H;Zhang S;Zou X;Yang Z;Li H;Chen W
通讯作者：
Chen W
影响因子：
34.3
作者：
Heer, Emily;Harper, Andrew;Fidler-Benaoudia, Miranda M.
通讯作者：
Fidler-Benaoudia, Miranda M.
影响因子：
50.5
作者：
Hashim, D.;Boffetta, P.;Negri, E.
通讯作者：
Negri, E.