Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells.
Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells.
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DOI：
10.1080/22221751.2022.2056523
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发表时间：
2022-12
影响因子：
13.2
通讯作者：
中科院分区：
文献类型：
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作者：
Influenza A virus still represents a noticeable epidemic risk to international public health at present, despite the extensive use of vaccines and anti-viral drugs. In the fight against pathogens, the immune defence lines consisting of diverse lymphocytes are indispensable for humans. However, the role of virus infection of lymphocytes and subsequent abnormal immune cell death remains to be explored. Different T cell subpopulations have distinct characterizations and functions, and we reveal the high heterogeneity of susceptibility to viral infection and biological responses such as apoptosis in various CD4+ T and CD8+ T cell subsets through single-cell transcriptome analyses. Effector memory CD8+ T cells (CD8+ TEM) that mediate protective memory are identified as the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection is established in CD8+ TEM and naïve CD8+ T cells, which indicate the mechanism of intracellular antiviral activities for inhibition of virus replication such as abnormal viral splicing efficiency, incomplete life cycles and up-regulation of interferon-stimulated genes in human T cells. These findings provide insights into understanding lymphopenia and the infectious mechanisms of pandemic influenza A virus and broad immune host–pathogen interactional atlas in primary human T cells.
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DOI：
10.1016/j.ijid.2004.07.014
发表时间：
2005-11
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
He Z;Zhao C;Dong Q;Zhuang H;Song S;Peng G;Dwyer DE
通讯作者：
Dwyer DE
DOI：
10.3390/v13050726
发表时间：
2021-04-21
期刊：
Viruses
影响因子：
--
作者：
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通讯作者：
Lal SK
影响因子：
3.8
作者：
Fan, Kewei;Jia, Yinping;Chen, Ji-Long
通讯作者：
Chen, Ji-Long
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影响因子：
5.2
作者：
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通讯作者：
Qu, Jieming
DOI：
10.1016/j.bbrc.2008.04.123
发表时间：
2008-07-04
影响因子：
3.1
作者：
Li, Yong-Gang;Thawatsupha, Pranee;Sawanpanyalert, Pathom
通讯作者：
Sawanpanyalert, Pathom