The diversity and specificity of functional connectivity across spatial and temporal scales.

The diversity and specificity of functional connectivity across spatial and temporal scales.
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功能连通性在时空尺度上的多样性和特异性。

DOI:
10.1016/j.neuroimage.2021.118692
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发表时间:
2021-12-15
期刊:
影响因子:
5.7
通讯作者:
Lewis, Christopher M.
Lewis, Christopher M.
中科院分区:
医学1区
文献类型:
--
作者:
Engel, Tatiana A.;Schoelvinck, Marieke L.;Lewis, Christopher M.

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人类的宏观神经成像模式已经揭示了大脑活动的组织,这些活动是根据行为需求重新组织的分布式功能网络。然而,宏观测量的固有粗粒度掩盖了每个局部区域中包含的许多单个神经元的响应和连接的多样性和特异性。新的动物侵入性方法能够以中尺度和微观尺度的分辨率记录和操纵神经活动,细胞类型特异性和时间精度低至毫秒。确定整个大脑的活动模式如何从跨空间和时间尺度的相互作用中产生,将使我们能够识别有助于全球大脑状态的关键电路机制,以及这些状态的动态活动如何实现适应性行为。
Macroscopic neuroimaging modalities in humans have revealed the organization of brain-wide activity into distributed functional networks that re-organize according to behavioral demands. However, the inherent coarse-graining of macroscopic measurements conceals the diversity and specificity in responses and connectivity of many individual neurons contained in each local region. New invasive approaches in animals enable recording and manipulating neural activity at meso- and microscale resolution, with cell-type specificity and temporal precision down to milliseconds. Determining how brain-wide activity patterns emerge from interactions across spatial and temporal scales will allow us to identify the key circuit mechanisms contributing to global brain states and how the dynamic activity of these states enables adaptive behavior.
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