The sensory representation of causally controlled objects.
The sensory representation of causally controlled objects.
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DOI：
10.1016/j.neuron.2020.12.001
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发表时间：
2021-02-17
期刊：
影响因子：
16.2
通讯作者：
Mrsic-Flogel TD
中科院分区：
文献类型：
--
作者：
Clancy KB;Mrsic-Flogel TD
对外部物体的有意控制是由我们对它们的感官经验提供信息的。为了研究因果关系是如何学习和影响的，我们设计了一个使用广域钙信号的脑机接口(BMI)任务。老鼠学会了在任意一对皮质区域中捕捉活动模式，以将视觉光标引导到目标位置以获得奖励。正常情况下相互关联的大脑区域可以迅速重新配置，以依赖感觉反馈的方式对光标进行控制。当专家而不是幼稚的动物控制光标时，高级视觉皮质更活跃。当老鼠控制光标时，高级视觉皮质中的单个神经元对光标的反应比被动观看时更强烈，当光标接近目标位置时，反应最大。因此，因果控制对象的表征对意图和与受试者目标的接近程度很敏感，潜在地加强了感觉反馈，从而允许更流畅的控制。小鼠通过大脑皮层区域的群体神经活动控制视觉光标动物可以解除正常相关皮质区域的关联来执行任务引入一项新规则触发对活动模式的随机探索受控对象以目标导向的方式引发更强大的感官反应Clancy和Mr ic-Flogel研究了对因果控制对象的感知与被动查看有何不同。老鼠学会了仅通过大脑活动来控制视觉光标。与被动光标查看期间相比，对受控光标的神经反应包括更多关于当前和未来光标位置的信息。
Intentional control over external objects is informed by our sensory experience of them. To study how causal relationships are learned and effected, we devised a brain machine interface (BMI) task using wide-field calcium signals. Mice learned to entrain activity patterns in arbitrary pairs of cortical regions to guide a visual cursor to a target location for reward. Brain areas that were normally correlated could be rapidly reconfigured to exert control over the cursor in a sensory-feedback-dependent manner. Higher visual cortex was more engaged when expert but not naive animals controlled the cursor. Individual neurons in higher visual cortex responded more strongly to the cursor when mice controlled it than when they passively viewed it, with the greatest response boosting as the cursor approached the target location. Thus, representations of causally controlled objects are sensitive to intention and proximity to the subject’s goal, potentially strengthening sensory feedback to allow more fluent control. Mice controlled a visual cursor using population neural activity in cortical areas Animals could decorrelate normally correlated cortical areas to perform the task Introduction of a new rule triggered stochastic exploration of activity patterns Controlled objects elicited more robust sensory responses in a goal-oriented manner Clancy and Mrsic-Flogel investigate how the perception of a causally controlled object is different than one passively viewed. Mice learn to control a visual cursor using brain activity alone. Neural responses to the controlled cursor include more information about the present and future cursor positions than during passive cursor viewing.
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