Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial.
Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial.
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DOI：
10.1186/1471-2377-7-20
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发表时间：
2007-07-16
期刊：
影响因子：
2.6
通讯作者：
Grosset DG
中科院分区：
文献类型：
--
作者：
Grosset KA;Grosset DG
帕金森病患者的用药往往不完善，尤其是用药时间不规律。测试了告知帕金森病患者持续多巴胺能假说（以鼓励定期服用药物）对药物依从性和运动控制的影响。患者被随机分为活性组（接受干预）或对照组（无额外信息）。在干预前后使用电子药瓶监测抗帕金森病药物的使用情况 3 个月，电子药瓶记录打开的日期和时间（MEMS®，Aardex，瑞士），并使用数据计算在正确时间间隔服用的剂量百分比。 43 名患者 (52%) 被随机分配接受主动咨询，40 名患者 (48%) 为对照组（标准管理）。干预效果（两组干预前后的时间依从性差异）为 13.4%（CI 5.1 至 21.7），p = 0.002。与对照组（4.5，CI 1.6 至 7.1）相比，帕金森运动评分没有显着变化（活性组 0.1，CI -3.4 至 3.7），p = 0.06。通过向患者提供额外的信息，可以改善计时依从性，但不能改善运动评分。治疗时机对于帕金森病的管理具有潜在的重要性。 NCT00361205
Medicine usage in Parkinson's disease patients is often imperfect, in particular irregular timing of medication. The effect of informing Parkinson's disease patients about the continuous dopaminergic hypothesis (to encourage regular medicine intake) on medication adherence and motor control was tested. Patients were randomised either to the active group (receiving the intervention) or control group (no extra information). Antiparkinson medicine usage was monitored for 3 months before and after the intervention using electronic pill bottles which record the date and time of opening (MEMS®, Aardex, Switzerland) and data used to calculate the percentage of doses taken at correct time intervals. 43 patients (52%) were randomised to active counselling, and 40 (48%) were controls (standard management). The intervention effect (difference in timing adherence pre- to post-intervention between the 2 groups) was 13.4% (CI 5.1 to 21.7), p = 0.002. Parkinson motor scores did not change significantly (active group 0.1, CI -3.4 to 3.7) versus controls (4.5, CI 1.6 to 7.1), p = 0.06. Timing adherence, but not motor scores, improves by providing patients with extra information. Therapy timing is of potential importance in Parkinson's disease management. NCT00361205
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影响因子：
8.6
作者：
Grosset, KA;Bone, I;Grosset, DG
通讯作者：
Grosset, DG
影响因子：
8.6
作者：
Parkin, SG;Gregory, RP;Aziz, TZ
通讯作者：
Aziz, TZ
影响因子：
6.7
作者：
Jenkinson, C;Fitzpatrick, R;Hyman, N
通讯作者：
Hyman, N
DOI：
10.1097/01.qai.0000014768.35851.db
发表时间：
2002-07-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
影响因子：
--
作者：
Hugen, PWH;Langebeek, N;Hekster, YA
通讯作者：
Hekster, YA
影响因子：
120.7
作者：
CRAMER, JA;MATTSON, RH;OUELLETTE, VL
通讯作者：
OUELLETTE, VL