Resting nailfold capillary blood flow in primary open-angle glaucoma.
Resting nailfold capillary blood flow in primary open-angle glaucoma.
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DOI：
10.1136/bjophthalmol-2018-311846
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Pasquale LR
中科院分区：
文献类型：
--
作者：
Cousins CC;Chou JC;Greenstein SH;Brauner SC;Shen LQ;Turalba AV;Houlihan P;Ritch R;Wiggs JL;Knepper PA;Pasquale LR
原发性开角型青光眼（POAG）的各种眼后段毛细血管床的血流动力学改变已被证实。POAG还可能涉及异常的非眼血流，并且不受眼内压（IOP）升高影响的甲襞毛细血管是容易评估的。我们使用视频毛细血管镜测量了67例POAG和63例对照组的静息甲襞毛细血管血流量。盲读片员跟踪连续配准图像序列帧之间的血柱空隙，测量血管直径并计算血流量。采用多元Logistic回归分析探讨原发性开角型青光眼患者甲襞毛细血管血流量与开角型青光眼的关系。在次要分析中，我们根据最大IOP和同时局部使用β受体阻滞剂对病例进行分层。POAG患者的平均（±SD）血流（单位：皮升/秒）为26.8±17.6，对照组为50.1±24.2（p<0.0001）。在调整血压和脉搏等人口统计学和临床因素后，静息甲襞血流量每增加1皮升/秒，POAG的发病几率就会降低6%（95%CI 0.92至0.96）（p<0.0001）。在按已知最大IOP分层的病例和按同时局部使用β受体阻滞剂分层的病例中，发现甲襞毛细血管血流量与POAG之间存在相似的关系。POAG患者静息时甲襞毛细血管血流量减少，与血压、脉搏和IOP等协变量无关。
An altered haemodynamic profile for various ocular posterior segment capillary beds has been documented in primary open-angle glaucoma (POAG). POAG may also involve abnormal non-ocular blood flow, and the nailfold capillaries, which are not affected by elevated intraocular pressure (IOP), are readily assessable. We measured resting nailfold capillary blood flow in 67 POAG and 63 control subjects using video capillaroscopy. Masked readers tracked blood column voids between consecutive, registered image sequence frames, measured vessel diameter and calculated blood flow. We used multiple logistic regression to investigate the relation between nailfold capillary blood flow and POAG. In secondary analyses, we stratified cases by maximum IOP and concurrent topical beta-blocker use. Mean (±SD) blood flow in picolitres per second was 26.8±17.6 for POAG cases and 50.1±24.2 for controls (p<0.0001). After adjustment for demographic and clinical factors including blood pressure and pulse, every picolitre per second increase in resting nailfold blood flow was associated with a 6% (95% CI 0.92 to 0.96) reduced odds of POAG (p<0.0001). Similar relations between nailfold capillary blood flow and POAG were found for cases stratified by maximum known IOP and for cases stratified by concurrent topical beta-blocker use. Reduced resting nailfold capillary blood flow is present in POAG independent of covariates such as blood pressure, pulse and IOP.
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DOI：
10.1186/1878-5085-4-14
发表时间：
2013-06-07
期刊：
The EPMA journal
影响因子：
--
作者：
Flammer J;Konieczka K;Flammer AJ
通讯作者：
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影响因子：
3.9
作者：
Cousins, C. C.;Kang, J. H.;Pasquale, L. R.
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Pasquale, L. R.
影响因子：
5.5
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Takehara, Kazuhiko
DOI：
10.1007/s13167-017-0097-3
发表时间：
2017-06
期刊：
The EPMA journal
影响因子：
--
作者：
Konieczka K;Choi HJ;Koch S;Fankhauser F;Schoetzau A;Kim DM
通讯作者：
Kim DM
影响因子：
3.9
作者：
Kang, J. H.;Loomis, S. J.;Pasquale, L. R.
通讯作者：
Pasquale, L. R.